Structure of PDB 2yaz Chain E

Receptor sequence
>2yazE (length=257) Species: 5664 (Leishmania major) [Search protein sequence]
NIPGAILHSLAELQDGLNAMIDPSWRAVRSLDNWALAITMESTELLDSYP
WKWWKNLNATPDLANVRIELVDIFHFSLSGAMQMRSTPDDEIPAASLKPL
KEVMTTFLPAKECTSDPYGFVFFPLTDTQNAIASFRNIIQLANAYRFDVI
IECIIYAAEDLGFNLVAYYIAKHTLNCIRQLSGYKDGSYVKVNNGVEDNS
LLHNCIKDVSLDEVLDADKYVQAWNSIMANVYEAFQIKESDRKDAERWFA
LAKENRL
3D structure
PDB2yaz The Crystal Structure of the Leishmania Major Deoxyuridine Triphosphate Nucleotidohydrolase in Complex with Nucleotide Analogues, Dump, and Deoxyuridine.
ChainE
Resolution2.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.1.23: dUTP diphosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 UMP E W60 W61 W53 W54 MOAD: Kd=7.3uM
BS02 UMP E N25 I28 W41 D79 H82 F83 N183 R186 Y191 N18 I21 W34 D72 H75 F76 N176 R179 Y184 MOAD: Kd=7.3uM
BS03 MG E E48 E76 D79 E41 E69 D72
Gene Ontology
Molecular Function
GO:0004170 dUTP diphosphatase activity
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
Cellular Component
GO:0005654 nucleoplasm

View graph for
Molecular Function
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Cellular Component
External links
PDB RCSB:2yaz, PDBe:2yaz, PDBj:2yaz
PDBsum2yaz
PubMed21454646
UniProtO15826

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