Structure of PDB 2x7f Chain E

Receptor sequence
>2x7fE (length=251) Species: 9606 (Homo sapiens) [Search protein sequence]
DLSALRDPAGIFELVELVGGQVYKGRHVKTGQLAAIKVMDVTGDEEEEIK
QEINMLKKYSHHRNIATYYGAFIKKDDQLWLVMEFCGAGSVTDLIKNKEE
WIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFTPYWMA
PEVIDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPAPRLKSK
KWSKKFQSFIESCLVKNHSQRPEQLMKHPFIRDQPNERQVRIQLKDHIDR
T
3D structure
PDB2x7f Crystal Structure of the Kinase Domain of Human Traf2- and Nck-Interacting Kinase with Wee1Chk1 Inhibitor
ChainE
Resolution2.8 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D153 K155 Q157 N158 D171 T191
Catalytic site (residue number reindexed from 1) D125 K127 Q129 N130 D143 T145
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 824 E V31 A52 M105 E106 C108 L160 V170 V18 A35 M83 E84 C86 L132 V142
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:2x7f, PDBe:2x7f, PDBj:2x7f
PDBsum2x7f
PubMed
UniProtQ9UKE5|TNIK_HUMAN TRAF2 and NCK-interacting protein kinase (Gene Name=TNIK)

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