Structure of PDB 2x00 Chain E

Receptor sequence
>2x00E (length=212) Species: 6500 (Aplysia californica) [Search protein sequence]
DDKLHSQANLMRLKSDLFNRSPMYPGPTKDDPLTVTLGFTLQDIVKADSS
TNEVDLVYYEQQRWKLNSLMWDPNEYGNITDFRTSAADIWTPDITAYSST
RPVQVLSPQIAVVTHDGSVMFIPAQRLSFMCDPTGVDSEEGATCAVKFGS
WVYSGFEIDLKTDTDQVDLSSYYASSKYEILSATQTRQVQHYSCCPEPYI
DVNLVVKFRERR
3D structure
PDB2x00 Structural Determinants in Phycotoxins and Achbp Conferring High Affinity Binding and Nicotinic Achr Antagonism.
ChainE
Resolution2.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GYN E Y55 I118 Y59 I122 MOAD: Kd=0.0047nM
PDBbind-CN: -logKd/Ki=11.33,Kd=4.7pM
BS02 GYN E Y93 K143 W147 Y188 C190 Y195 Y97 K147 W151 Y192 C194 Y199 MOAD: Kd=0.0047nM
PDBbind-CN: -logKd/Ki=11.33,Kd=4.7pM
Gene Ontology
Molecular Function
GO:0004888 transmembrane signaling receptor activity
GO:0005216 monoatomic ion channel activity
GO:0005230 extracellular ligand-gated monoatomic ion channel activity
Biological Process
GO:0006811 monoatomic ion transport
GO:0034220 monoatomic ion transmembrane transport
Cellular Component
GO:0016020 membrane

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Cellular Component
External links
PDB RCSB:2x00, PDBe:2x00, PDBj:2x00
PDBsum2x00
PubMed20224036
UniProtQ8WSF8

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