Structure of PDB 2wn9 Chain E

Receptor sequence
>2wn9E (length=214) Species: 6500 (Aplysia californica) [Search protein sequence]
DYKDDDDKLHSQANLMRLKSDLFNRSYPGPTKDDPLTVTLGFTLQDIVKA
DSSTNEVDLVYYEQQRWKLNSLMWDPNEYGNITDFRTSAADIWTPDITAY
SSTRPVQVLSPQIAVVTHDGSVMFIPAQRLSFMCDPTGVDSEEGATCAVK
FGSWVYSGFEIDLKTDTDQVDLSSYYASSKYEILSATQTRQVQHYSCCPE
PYIDVNLVVKFRER
3D structure
PDB2wn9 Structural determinants for interaction of partial agonists with acetylcholine binding protein and neuronal alpha7 nicotinic acetylcholine receptor.
ChainE
Resolution1.75 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZY5 E T36 I118 D164 S167 T43 I125 D171 S174 MOAD: Kd=3nM
PDBbind-CN: -logKd/Ki=8.52,Kd=3.0nM
BS02 ZY5 E Y93 W147 Y188 C190 Y195 Y100 W154 Y195 C197 Y202 MOAD: Kd=3nM
PDBbind-CN: -logKd/Ki=8.52,Kd=3.0nM
Gene Ontology
Molecular Function
GO:0004888 transmembrane signaling receptor activity
GO:0005216 monoatomic ion channel activity
GO:0005230 extracellular ligand-gated monoatomic ion channel activity
Biological Process
GO:0006811 monoatomic ion transport
GO:0034220 monoatomic ion transmembrane transport
Cellular Component
GO:0016020 membrane

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Cellular Component
External links
PDB RCSB:2wn9, PDBe:2wn9, PDBj:2wn9
PDBsum2wn9
PubMed19696737
UniProtQ8WSF8

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