Structure of PDB 2w4i Chain E

Receptor sequence
>2w4iE (length=254) Species: 210 (Helicobacter pylori) [Search protein sequence]
MKIGVFDSGVGGFSVLKSLLKARLFDEIIYYGDSARVPYGTKDPTTIKQF
GLEALDFFKPHEIELLIVACNTASALALEEMQKYSKIPIVGVIEPSILAI
KRQVEDKNAPILVLGTKATIQSNAYDNALKQQGYLNISHLATSLFVPLIE
ESILEGELLETCMHYYFTPLEILPEVIILGCTHFPLIAQKIEGYFMGHFA
LPTPPLLIHSGDAIVEYLQQKYALKNNACTFPKVEFHASGDVIWLERQAK
EWLK
3D structure
PDB2w4i Potent and selective inhibitors of Helicobacter pylori glutamate racemase (MurI): pyridodiazepine amines.
ChainE
Resolution1.87 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 5.1.1.3: glutamate racemase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 DGL E S8 P38 Y39 G40 C70 N71 T72 C181 T182 H183 S8 P38 Y39 G40 C70 N71 T72 C181 T182 H183
BS02 VGA E T41 S143 V146 P147 E150 E151 T41 S143 V146 P147 E150 E151 MOAD: ic50=0.5uM
BindingDB: IC50=500nM
Gene Ontology
Molecular Function
GO:0008881 glutamate racemase activity
GO:0016853 isomerase activity
GO:0016855 racemase and epimerase activity, acting on amino acids and derivatives
GO:0036361 racemase activity, acting on amino acids and derivatives
GO:0042802 identical protein binding
Biological Process
GO:0008360 regulation of cell shape
GO:0009252 peptidoglycan biosynthetic process
GO:0071555 cell wall organization

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Molecular Function
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Biological Process
External links
PDB RCSB:2w4i, PDBe:2w4i, PDBj:2w4i
PDBsum2w4i
PubMed19097892
UniProtQ9ZLT0|MURI_HELPJ Glutamate racemase (Gene Name=murI)

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