Structure of PDB 2v1o Chain E

Receptor sequence
>2v1oE (length=148) Species: 10090 (Mus musculus) [Search protein sequence]
AMRIMRPDDANVAGNVHGGTILKMIEEAGAIISTRHCNSQNGERCVAALA
RVERTDFLSPMCIGEVAHVSAEITYTSKHSVEVQVHVMSENILTGTKKLT
NKATLWYVPLSLKNVDKVLEVPPIVYLRQEQEEEGRKRYEAQKLERME
3D structure
PDB2v1o Structural Basis for Recruitment of Tandem Hotdog Domains in Acyl-Coa Thioesterase 7 and its Role in Inflammation.
ChainE
Resolution1.78 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.2.2: palmitoyl-CoA hydrolase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 COA E A61 L62 A63 R64 S90 K91 H92 V121 Y152 Q155 K156 R159 A48 L49 A50 R51 S77 K78 H79 V108 Y139 Q142 K143 R146
BS02 COA E V29 D69 F70 L71 S72 P73 V16 D56 F57 L58 S59 P60
Gene Ontology
Molecular Function
GO:0016790 thiolester hydrolase activity

View graph for
Molecular Function
External links
PDB RCSB:2v1o, PDBe:2v1o, PDBj:2v1o
PDBsum2v1o
PubMed17563367
UniProtQ91V12|BACH_MOUSE Cytosolic acyl coenzyme A thioester hydrolase (Gene Name=Acot7)

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