Structure of PDB 2qr1 Chain E

Receptor sequence
>2qr1E (length=324) Species: 4896 (Schizosaccharomyces pombe) [Search protein sequence]
DVQETQKGALKEIQAFIRSRTSYDVLPTSFRLIVFDVTLFVKTSLSLLTL
NNIVSAPLWDSEANKFAGLLTMADFVNVIKYYYQSSSFPEAIAEIDKFRL
LGLREVERKIGAIPPETIYVHPMHSLMDACLAMSKSRARRIPLIDVDGET
GSEMIVSVLTQYRILKFISMNCKETAMLRVPLNQMTIGTWSNLATASMET
KVYDVIKMLAEKNISAVPIVNSEGTLLNVYESVDVMHLIQDGDYSNLDLS
VGEALLKRPANFDGVHTCRATDRLDGIFDAIKHSRVHRLFVVDENLKLEG
ILSLADILNYIIYDKTTDNFESAV
3D structure
PDB2qr1 Structural Insight into AMPK Regulation: ADP Comes into Play.
ChainE
Resolution2.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP E R139 R141 T191 A196 I216 S217 A218 R290 S305 D308 R137 R139 T189 A194 I214 S215 A216 R288 S303 D306
BS02 ADP E R33 L34 I35 I55 R142 T162 Y164 R165 R287 H289 R31 L32 I33 I53 R140 T160 Y162 R163 R285 H287
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016208 AMP binding
GO:0019887 protein kinase regulator activity
GO:0019901 protein kinase binding
GO:0030295 protein kinase activator activity
GO:0043531 ADP binding
Biological Process
GO:0006357 regulation of transcription by RNA polymerase II
GO:0007165 signal transduction
GO:0010514 induction of conjugation with cellular fusion
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0031588 nucleotide-activated protein kinase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2qr1, PDBe:2qr1, PDBj:2qr1
PDBsum2qr1
PubMed17937917
UniProtQ10343|AAKG_SCHPO 5'-AMP-activated protein kinase subunit gamma (Gene Name=cbs2)

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