Structure of PDB 2ojw Chain E

Receptor sequence
>2ojwE (length=354) Species: 9606 (Homo sapiens) [Search protein sequence]
ASSHLNKGIKQVYMSLPQGEKVQAMYIWIDGTGEGLRCKTRTLDSEPKCV
EELPEWNFDGSSTLQSEGSNSDMYLVPAAMFRDPFRKDPNKLVLCEVFKY
NRRPAETNLRHTCKRIMDMVSNQHPWFGMEQEYTLMGTDGHPFGWPSNGF
PGPQGPYYCGVGADRAYGRDIVEAHYRACLYAGVKIAGTNAEVMPAQWEF
QIGPCEGISMGDHLWVARFILHRVCEDFGVIATFDPKPIPGNWNGAGCHT
NFSTKAMREENGLKYIEEAIEKLSKRHQYHIRAYDPKGGLDNARRLSNIN
DFSAGVANRSASIRIPRTVGQEKKGYFEDRRPSANCDPFSVTEALIRTCL
LNET
3D structure
PDB2ojw Crystal structures of mammalian glutamine synthetases illustrate substrate-induced conformational changes and provide opportunities for drug and herbicide design.
ChainE
Resolution2.05 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.1.225: protein S-acyltransferase.
6.3.1.2: glutamine synthetase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MN E E136 E196 E203 E132 E192 E199
BS02 MN E E134 H253 E338 E130 H249 E328
BS03 MN E E134 E203 E130 E199
BS04 PO4 E E134 E203 H253 R319 E130 E199 H249 R309
BS05 ADP E W130 E134 Q205 G207 P208 N255 S257 R319 R324 Y336 W126 E130 Q201 G203 P204 N251 S253 R309 R314 Y326
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004356 glutamine synthetase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016740 transferase activity
GO:0016874 ligase activity
GO:0019706 protein-cysteine S-palmitoyltransferase activity
GO:0042802 identical protein binding
GO:0046872 metal ion binding
Biological Process
GO:0001525 angiogenesis
GO:0006538 glutamate catabolic process
GO:0006542 glutamine biosynthetic process
GO:0008283 cell population proliferation
GO:0009267 cellular response to starvation
GO:0009749 response to glucose
GO:0010594 regulation of endothelial cell migration
GO:0018345 protein palmitoylation
GO:0042254 ribosome biogenesis
GO:1903670 regulation of sprouting angiogenesis
GO:1904749 regulation of protein localization to nucleolus
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005783 endoplasmic reticulum
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0044297 cell body
GO:0070062 extracellular exosome
GO:0097386 glial cell projection

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2ojw, PDBe:2ojw, PDBj:2ojw
PDBsum2ojw
PubMed18005987
UniProtP15104|GLNA_HUMAN Glutamine synthetase (Gene Name=GLUL)

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