Structure of PDB 2oax Chain E

Receptor sequence
>2oaxE (length=234) Species: 9606 (Homo sapiens) [Search protein sequence]
PVMVLENIEPEIVYAGYDSSKPDTAENLLSTLNRLAGKQMIQVVKWAKVL
PGFKNLPLEDQITLIQYSWMCLLSFALSWRSYKHTNSQFLYFAPDLVFNE
EKMHQSAMYELCQGMHQISLQFVRLQLTFEEYTIMKVLLLLSTIPKDGLK
SQAAFEEMRTNYIKELRKMVQRFYQLTKLLDSMHDLVSDLLEFCFYTFRE
SHALKVEFPAMLVEIISDQLPKVESGNAKPLYFH
3D structure
PDB2oax Structural basis of spirolactone recognition by the mineralocorticoid receptor
ChainE
Resolution2.29 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SNL E L766 L769 N770 L772 Q776 M807 L810 L814 F829 M845 M852 L938 F941 C942 F956 L29 L32 N33 L35 Q39 M70 L73 L77 F92 M108 M115 L190 F193 C194 F208 BindingDB: IC50=11nM,Ki=2.323nM
External links
PDB RCSB:2oax, PDBe:2oax, PDBj:2oax
PDBsum2oax
PubMed17569793
UniProtP08235|MCR_HUMAN Mineralocorticoid receptor (Gene Name=NR3C2)

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