Structure of PDB 2gm1 Chain E

Receptor sequence
>2gm1E (length=322) Species: 9606 (Homo sapiens) [Search protein sequence]
KNIQVVVRCRPFNLAERKASAHSIVECDPVRKEVSVRTGSSRKTYTFDMV
FGASTKQIDVYRSVVCPILDEVIMGYNCTIFAYGQTGTGKTFTMEGERSP
NEEYTWEEDPLAGIIPRTLHQIFEKLTDNGTEFSVKVSLLEIYNEELFDL
LNPSSDVSERLQMFDDPRNKRGVIIKGLEEITVHNKDEVYQILEKGAAKR
TTAATLMNAYSSRSHSVFSVTIHMKVKIGKLNLVDLAGSENININQSLLT
LGRVITALVERTPHVPYRESKLTRILQDSLGGRTRTSIIATISPASLNLE
ETLSTLEYAHRAKNILNKPEVN
3D structure
PDB2gm1 Synthesis and SAR of pyrrolotriazine-4-one based Eg5 inhibitors.
ChainE
Resolution2.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP E L30 K34 L14 K18
BS02 MG E S232 S235 S211 S214
BS03 2AZ E E116 G117 E118 R119 W127 I136 P137 Y211 L214 E215 R221 E95 G96 E97 R98 W106 I115 P116 Y190 L193 E194 R200 MOAD: ic50=0.1uM
BindingDB: IC50=100nM
BS04 ADP E P27 T107 G108 G110 K111 T112 F113 E118 P11 T86 G87 G89 K90 T91 F92 E97
Gene Ontology
Molecular Function
GO:0003777 microtubule motor activity
GO:0005524 ATP binding
GO:0008017 microtubule binding
Biological Process
GO:0007018 microtubule-based movement

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Molecular Function
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Biological Process
External links
PDB RCSB:2gm1, PDBe:2gm1, PDBj:2gm1
PDBsum2gm1
PubMed16730979
UniProtP52732|KIF11_HUMAN Kinesin-like protein KIF11 (Gene Name=KIF11)

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