Structure of PDB 2ewp Chain E

Receptor sequence
>2ewpE (length=214) Species: 9606 (Homo sapiens) [Search protein sequence]
IVSHLLVAEPEKIYAMPDPTVPDSDIKALTTLCDLADRELVVIIGWAKHI
PGFSTLSLADQMSLLQSAWMEILILGVVYRSLSFEDELVYADDYIMDEDQ
SKLAGLLDLNNAILQLVKKYKSMKLEKEEFVTLKAIALANSDSMHIEDVE
AVQKLQDVLHEALQDYEEDPRRAGKMLMTLPLLRQTSTKAVQHFYNIKLE
GKVPMHKLFLEMLE
3D structure
PDB2ewp Structure-guided synthesis of tamoxifen analogs with improved selectivity for the orphan ERRgamma.
ChainE
Resolution2.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 TXF E C269 A272 D273 E275 L309 V313 Y326 L345 N346 I349 F435 L440 C33 A36 D37 E39 L73 V77 Y90 L109 N110 I113 F194 L199 MOAD: ic50=0.079uM
BindingDB: IC50=77nM
External links
PDB RCSB:2ewp, PDBe:2ewp, PDBj:2ewp
PDBsum2ewp
PubMed16307879
UniProtP62508|ERR3_HUMAN Estrogen-related receptor gamma (Gene Name=ESRRG)

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