Structure of PDB 2c92 Chain E

Receptor sequence
>2c92E (length=146) Species: 1773 (Mycobacterium tuberculosis) [Search protein sequence]
ASGVRLAIVASSWHGKICDALLDGARKVAAGCGLDDPTVVRVLGAIEIPV
VAQELARNHDAVVALGVVIRGQTPHFDYVCDAVTQGLTRVSLDSSTPIAN
GVLTTNTEEQALDRAGLPTSAEDKGAQATVAALATALTLRELRAHS
3D structure
PDB2c92 Structural and Thermodynamic Insights Into the Binding Mode of Five Novel Inhibitors of Lumazine Synthase from Mycobacterium Tuberculosis.
ChainE
Resolution1.6 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H89
Catalytic site (residue number reindexed from 1) H75
Enzyme Commision number 2.5.1.78: 6,7-dimethyl-8-ribityllumazine synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 TP6 E A113 N114 R128 K138 A99 N100 R114 K124 MOAD: Ka=474900M^-1
BS02 TP6 E W27 G58 A59 I60 E61 V81 V82 I83 G85 Q86 T87 W13 G44 A45 I46 E47 V67 V68 I69 G71 Q72 T73 MOAD: Ka=474900M^-1
Gene Ontology
Molecular Function
GO:0000906 6,7-dimethyl-8-ribityllumazine synthase activity
GO:0016740 transferase activity
Biological Process
GO:0009231 riboflavin biosynthetic process
Cellular Component
GO:0005829 cytosol
GO:0009349 riboflavin synthase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2c92, PDBe:2c92, PDBj:2c92
PDBsum2c92
PubMed16984393
UniProtP9WHE9|RISB_MYCTU 6,7-dimethyl-8-ribityllumazine synthase (Gene Name=ribH)

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