Structure of PDB 2bqz Chain E

Receptor sequence

>2bqzE (length=161) Species: 9606 (Homo sapiens)

RKSKAELQSEERKRIDELIESGKEEGMKIDLIDGKGRGVIATKQFSRGDF
VVEYHGDLIEITDAKKREALYAQDPSTGCYMYYFQYLSKTYCVDATRETN
RLGRLINHSKCGNCQTKLHDIDGVPHLILIASRDIAAGEELLYDYGDRSK
ASIEAHPWLKH

3D structure

• PDB: 2bqz Specificity and Mechanism of the Histone Methyltransferase Pr-Set7
• Chain: E
• Resolution: 1.5 Å

Enzymatic activity

• Enzyme Commision number: 2.1.1.-
  2.1.1.361: [histone H4]-lysine(20) N-methyltransferase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	E	Y245 E259 Y262 A263 D265 T268 G269 C270 M272 Y273 Y274 Q276 T307 L309 Y334 Y336 G337 D338 R339 S343 H347 W349	Y54 E68 Y71 A72 D74 T77 G78 C79 M81 Y82 Y83 Q85 T116 L118 Y143 Y145 G146 D147 R148 S152 H156 W158
BS02	SAH	E	K226 R228 Y271 R295 L296 N298 H299 Y336 W349	K35 R37 Y80 R104 L105 N107 H108 Y145 W158

Gene Ontology

Molecular Function

• GO:0042799 histone H4K20 methyltransferase activity

External links

• PDB: RCSB:2bqz, PDBe:2bqz, PDBj:2bqz
• PDBsum: 2bqz
• PubMed: 15933069
• UniProt: Q9NQR1|KMT5A_HUMAN N-lysine methyltransferase KMT5A (Gene Name=KMT5A)