Structure of PDB 1zos Chain E

Receptor sequence
>1zosE (length=230) Species: 171101 (Streptococcus pneumoniae R6) [Search protein sequence]
MKIGIIAAMPEELAYLVQHLDNTQEQVVLGNTYHTGTIASHEVVLVESGI
GKVMSAMSVAILADHFQVDALINTGSAGAVAEGIAVGDVVIADKLAYHDV
DVTAFGYAYGQMAQQPLYFESDKTFVAQIQESLSQLDQNWHLGLIATGDS
FVAGNDKIEAIKSHFPEVLAVEMEGAAIAQAAHTLNLPVLVIRAMSDNAN
HEANIFFDEFIIEAGRRSAQVLLAFLKALD
3D structure
PDB1zos Structure and inhibition of a quorum sensing target from Streptococcus pneumoniae.
ChainE
Resolution1.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.2.2.9: adenosylhomocysteine nucleosidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MTM E S76 A77 G78 F151 V152 E172 M173 E174 S196 D197 A199 F207 S76 A77 G78 F151 V152 E172 M173 E174 S196 D197 A199 F207 MOAD: Ki=1uM
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0008782 adenosylhomocysteine nucleosidase activity
GO:0008930 methylthioadenosine nucleosidase activity
GO:0016798 hydrolase activity, acting on glycosyl bonds
Biological Process
GO:0009086 methionine biosynthetic process
GO:0009116 nucleoside metabolic process
GO:0009164 nucleoside catabolic process
GO:0019284 L-methionine salvage from S-adenosylmethionine
GO:0019509 L-methionine salvage from methylthioadenosine
Cellular Component
GO:0005829 cytosol

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Cellular Component
External links
PDB RCSB:1zos, PDBe:1zos, PDBj:1zos
PDBsum1zos
PubMed17059210
UniProtQ8DQ16

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