Structure of PDB 1zm2 Chain E

Receptor sequence
>1zm2E (length=823) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]
VAFTVDQMRSLMDKVTNVRNMSVIAHVDHGKSTLTDSLVQRAGIISAGIT
IKSTAISLYSEMSDEDVKEIKQKTDGNSFLINLIDSPGHVDFSSEVTAAL
RVTDGALVVVDTIEGVCVQTETVLRQALGERIKPVVVINKVDRALLELQV
SKEDLYQTFARTVESVNVIVSTYADEVLGDVQVYPARGTVAFGSGLHGWA
FTIRQFATRYAKKFGVDKAKMMDRLWGDSFFNPKTKKWTNKDTDAEGKPL
ERAFNMFILDPIFRLFTAIMNFKKDEIPVLLEKLEIVLKGDEKDLEGKAL
LKVVMRKFLPAADALLEMIVLHLPSPVTAQAYRAEQLYEGPADDANCIAI
KNCDPKADLMLYVSKMVPTSDKGRFYAFGRVFAGTVKSGQKVRIQGPNYV
PGKKDDLFIKAIQRVVLMMGRFVEPIDDCPAGNIIGLVGIDQFLLKTGTL
TTSETAHNMKVMKFSVSPVVQVAVEVKNANDLPKLVEGLKRLSKSDPCVL
TYMSESGEHIVAGTGELHLEICLQDLEHDHAGVPLKISPPVVAYRETVES
ESSQTALSKSPNKHNRIYLKAEPIDEEVSLAIENGIINPRDDFKARARIM
ADDYGWDVTDARKIWCFGPDGNGPNLVIDQTKAVQYLHEIKDSVVAAFQW
ATKEGPIFGEEMRSVRVNILDVTLHADAIHRGGGQIIPTMRRATYAGFLL
ADPKIQEPVFLVEIQCPEQAVGGIYSVLNKKRGQVVSEEQRPGTPLFTVK
AYLPVNESFGFTGELRQATGGQAFPQMVFDHWSTLGSDPLDPTSKAGEIV
LAARKRHGMKEEVPGWQEYYDKL
3D structure
PDB1zm2 Exotoxin A-eEF2 complex structure indicates ADP ribosylation by ribosome mimicry.
ChainE
Resolution3.07 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.5.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 APR E H694 D696 X699 H675 D677 X680
Gene Ontology
Molecular Function
GO:0003746 translation elongation factor activity
GO:0003924 GTPase activity
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0016787 hydrolase activity
GO:0019843 rRNA binding
GO:0042802 identical protein binding
GO:0043022 ribosome binding
GO:0051087 protein-folding chaperone binding
Biological Process
GO:0006412 translation
GO:0006414 translational elongation
GO:0045901 positive regulation of translational elongation
GO:1990145 maintenance of translational fidelity
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:1990904 ribonucleoprotein complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1zm2, PDBe:1zm2, PDBj:1zm2
PDBsum1zm2
PubMed16107839
UniProtP32324|EF2_YEAST Elongation factor 2 (Gene Name=EFT1)

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