Structure of PDB 1xsl Chain E

Receptor sequence
>1xslE (length=325) Species: 9606 (Homo sapiens) [Search protein sequence]
NHNLHITEKLEVLAKAYSVQGDKWRALGYAKAINALKSFHKPVTSYQEAC
SIPGIGKRMAEKIIEILESGHLRKLDHISESVPVLELFSNIWGAGTKTAQ
MWYQQGFRSLEDIRSQASLTTQQAIGLKHYSDFLERMPREEATEIEQTVQ
KAAQAFNSGLLCVACGSYRRGKATCGDVDVLITHPDGRSHRGIFSRLLDS
LRQEGFLTDDLVSQEENGQQQKYLGVCRLPGPGRRHRRLDIIVVPYSEFA
CALLYFTGSAHFNRSMRALAKTKGMSLSEHALSTAVVRNTHGCKVGPGRV
LPTPTEKDVFRLLGLPYREPAERDW
3D structure
PDB1xsl A closed conformation for the Pol lambda catalytic cycle.
ChainE
Resolution2.3 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D427 D429 D490
Catalytic site (residue number reindexed from 1) D177 D179 D240
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
4.2.99.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna E W274 T371 E465 E466 Y505 R517 K521 W24 T121 E215 E216 Y255 R267 K271
BS02 dna E W342 G343 A344 G345 K347 T348 K472 W92 G93 A94 G95 K97 T98 K222
BS03 dna E Y267 W274 R275 Y279 G304 G306 R308 M309 K312 Y17 W24 R25 Y29 G54 G56 R58 M59 K62
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
GO:0016779 nucleotidyltransferase activity
GO:0034061 DNA polymerase activity
Biological Process
GO:0006281 DNA repair

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:1xsl, PDBe:1xsl, PDBj:1xsl
PDBsum1xsl
PubMed15608652
UniProtQ9UGP5|DPOLL_HUMAN DNA polymerase lambda (Gene Name=POLL)

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