Structure of PDB 1xm2 Chain E

Receptor sequence
>1xm2E (length=149) Species: 9606 (Homo sapiens) [Search protein sequence]
APVEVTYKNMRFLITHNPTNATLNKFIEELKKYGVTTIVRVCEATYDTTL
VEKEGIHVLDWPFDDGAPPSNQIVDDWLSLVKIKFREEPGCCIAVHSVAG
LGRAPVLVALALIEGGMKYEDAVQFIRQKRRGAFNSKQLLYLEKYRPKM
3D structure
PDB1xm2 Trimeric structure of PRL-1 phosphatase reveals an active enzyme conformation and regulation mechanisms
ChainE
Resolution2.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.3.48: protein-tyrosine-phosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SO4 E S104 G109 R110 S97 G102 R103
Gene Ontology
Molecular Function
GO:0004721 phosphoprotein phosphatase activity
GO:0004725 protein tyrosine phosphatase activity
GO:0005515 protein binding
Biological Process
GO:0006470 protein dephosphorylation
GO:0016311 dephosphorylation
GO:0030335 positive regulation of cell migration
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005768 endosome
GO:0005769 early endosome
GO:0005783 endoplasmic reticulum
GO:0005819 spindle
GO:0005856 cytoskeleton
GO:0005886 plasma membrane
GO:0009898 cytoplasmic side of plasma membrane

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Cellular Component
External links
PDB RCSB:1xm2, PDBe:1xm2, PDBj:1xm2
PDBsum1xm2
PubMed15571731
UniProtQ93096|TP4A1_HUMAN Protein tyrosine phosphatase type IVA 1 (Gene Name=PTP4A1)

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