Structure of PDB 1xls Chain E

Receptor sequence
>1xlsE (length=242) Species: 10090 (Mus musculus) [Search protein sequence]
NQQQKELVQILLGAHTRHVGPLFDQFVQFRPPAYLFMHHRPFQPRGPVLP
LLTHFADINTFMVQQIIKFTKDLPLFRSLTMEDQISLLKGAAVEILHISL
NTTFCLQTENFFCGPLCYKMEDAVHAGFQYEFLESILHFHKNLKGLHLQE
PEYVLMAATALFSPDRPGVTQREEIDQLQEEMALILNNHIMEQQSRLQSR
FLYAKLMGLLADLRSINNAYSYELQRLEELSAMTPLLGEICS
3D structure
PDB1xls The nuclear xenobiotic receptor CAR: structural determinants of constitutive activation and heterodimerization.
ChainE
Resolution2.96 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide E I183 K184 K187 R193 M197 I201 K205 L352 E355 I67 K68 K71 R77 M81 I85 K89 L236 E239
BS02 TCD E N175 F227 Y234 F244 F248 I252 Y336 E339 L346 L353 N59 F111 Y118 F128 F132 I136 Y220 E223 L230 L237
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription

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Molecular Function
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Biological Process
External links
PDB RCSB:1xls, PDBe:1xls, PDBj:1xls
PDBsum1xls
PubMed15610733
UniProtO35627|NR1I3_MOUSE Nuclear receptor subfamily 1 group I member 3 (Gene Name=Nr1i3)

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