Structure of PDB 1x27 Chain E

Receptor sequence
>1x27E (length=163) Species: 9606 (Homo sapiens) [Search protein sequence]
NLVIALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKAQSLTTGQEGFIPF
NFVAKANSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSF
SLSVRDFDQNQGEVVKHYKIRNLDNGGFYISPRITFPGLHELVRHYTNAS
DGLCTRLSRPCQT
3D structure
PDB1x27 Molecular basis for regulation of Src by the docking protein p130Cas
ChainE
Resolution2.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide E R134 R154 S156 E157 S158 S164 K179 H180 Y181 K182 S194 G215 C217 R71 R91 S93 E94 S95 S101 K116 H117 Y118 K119 S131 G152 C154
External links
PDB RCSB:1x27, PDBe:1x27, PDBj:1x27
PDBsum1x27
PubMed16245368
UniProtP06239|LCK_HUMAN Tyrosine-protein kinase Lck (Gene Name=LCK)

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