Structure of PDB 1wyv Chain E

Receptor sequence
>1wyvE (length=437) Species: 300852 (Thermus thermophilus HB8) [Search protein sequence]
MDYTPHTEEEIREMLRRVGAASLEDLFAHLPKEILSPPIDLPEPLPEWKV
LEELRRLAAQNLPAHKAFLGGGVRSHHVPPVVQALAARGEFLTAYTPYQP
EVSQGVLQATFEYQTMIAELAGLEIANASMYDGATALAEGVLLALRETGR
MGVLVSQGVHPEYRAVLRAYLEAVGAKLLTLPLEGGRTPLPEVGEEVGAV
VVQNPNFLGALEDLGPFAEAAHGAGALFVAVADPLSLGVLKPPGAYGADI
AVGDGQSLGLPMGFGGPHFGFLATKKAFVRQLPGRLVSETVDVEGRRGFI
LTLQAREQYIRRAKAKSNITTNAQLTALMGAMYLAALGPEGLREVALKSV
EMAHKLHALLLEVPGVRPFTPKPFFNEFALALPKDPEAVRRALAERGFHG
ATPVPREYGENLALFAATELHEEEDLLALREALKEVL
3D structure
PDB1wyv Structure of P-protein of the glycine cleavage system: implications for nonketotic hyperglycinemia
ChainE
Resolution2.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.4.4.2: glycine dehydrogenase (aminomethyl-transferring).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PLP E T320 T321 T320 T321
BS02 AOA E Y95 Y98 Q308 T320 Y95 Y98 Q308 T320
Gene Ontology
Molecular Function
GO:0004375 glycine dehydrogenase (decarboxylating) activity
GO:0016491 oxidoreductase activity
Biological Process
GO:0006546 glycine catabolic process
GO:0009116 nucleoside metabolic process
GO:0019464 glycine decarboxylation via glycine cleavage system

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Molecular Function
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Biological Process
External links
PDB RCSB:1wyv, PDBe:1wyv, PDBj:1wyv
PDBsum1wyv
PubMed15791207
UniProtQ5SKW8

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