Structure of PDB 1w4r Chain E

Receptor sequence
>1w4rE (length=160) Species: 9606 (Homo sapiens) [Search protein sequence]
RGQIQVILGPMFSGKSTELMRRVRRFQIAQYKCLVIKYAKDTRALPACLL
RDVAQEALGVAVIGIDEGQFFPDIVEFCEAMANAGKTVIVAALDGTFQRK
PFGAILNLVPLAESVVKLTAVCMECFREAAYTKRLGTEKEVEVIGGADKY
HSVCRLCYFK
3D structure
PDB1w4r Structure of a Type II Thymidine Kinase with Bound Dttp
ChainE
Resolution1.83 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.1.21: thymidine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 TTP E M28 G31 K32 S33 D58 D97 E98 Q100 F101 L124 T127 F128 F133 T163 V172 E173 V174 G176 Y181 M11 G14 K15 S16 D41 D66 E67 Q69 F70 L93 T96 F97 F102 T132 V141 E142 V143 G145 Y150
BS02 ZN E C153 C156 C185 C188 C122 C125 C154 C157
Gene Ontology
Molecular Function
GO:0004797 thymidine kinase activity
GO:0005524 ATP binding

View graph for
Molecular Function
External links
PDB RCSB:1w4r, PDBe:1w4r, PDBj:1w4r
PDBsum1w4r
PubMed15733844
UniProtP04183|KITH_HUMAN Thymidine kinase, cytosolic (Gene Name=TK1)

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