Structure of PDB 1tu3 Chain E

Receptor sequence
>1tu3E (length=167) Species: 9606 (Homo sapiens) [Search protein sequence]
NKICQFKLVLLGESAVGKSSLVLRFVKGQFHEFQESTIGAAFLTQTVCLD
DTTVKFEIWDTAGQERYHSLAPMYYRGAQAAIVVYDITNEESFARAKNWV
KELQRQASPNIVIALSGNKADLANKRAVDFQEAQSYADDNSLLFMETSAK
TSMNVNEIFMAIAKKLP
3D structure
PDB1tu3 Structural basis of Rab5-Rabaptin5 interaction in endocytosis
ChainE
Resolution2.31 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.5.2: small monomeric GTPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG E S34 T52 S19 T37
BS02 GNP E A30 G32 K33 S34 S35 F45 E47 Q49 T52 G78 N133 K134 D136 L137 S163 A164 K165 A15 G17 K18 S19 S20 F30 E32 Q34 T37 G63 N118 K119 D121 L122 S148 A149 K150
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding

View graph for
Molecular Function
External links
PDB RCSB:1tu3, PDBe:1tu3, PDBj:1tu3
PDBsum1tu3
PubMed15378032
UniProtP20339|RAB5A_HUMAN Ras-related protein Rab-5A (Gene Name=RAB5A)

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