Structure of PDB 1ssp Chain E

Receptor sequence
>1sspE (length=223) Species: 9606 (Homo sapiens) [Search protein sequence]
MEFFGESWKKHLSGEFGKPYFIKLMGFVAEERKHYTVYPPPHQVFTWTQM
CDIKDVKVVILGQDPYHGPNQAHGLCFSVQRPVPPPPSLENIYKELSTDI
EDFVHPGHGDLSGWAKQGVLLLNAVLTVRAHQANSHKERGWEQFTDAVVS
WLNQNSNGLVFLLWGSYAQKKGSAIDRKRHHVLQTAHPSPLSVYRGFFGC
RHFSKTNELLQKSGKKPIDWKEL
3D structure
PDB1ssp Base excision repair initiation revealed by crystal structures and binding kinetics of human uracil-DNA glycosylase with DNA.
ChainE
Resolution1.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.2.2.27: uracil-DNA glycosylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna E D145 Y147 P168 S169 G246 S247 H268 S270 P271 L272 S273 R276 D64 Y66 P87 S88 G165 S166 H187 S189 P190 L191 S192 R195 PDBbind-CN: Kd=48nM
BS02 URA E G143 Q144 D145 Y147 C157 F158 N204 H268 G62 Q63 D64 Y66 C76 F77 N123 H187
Gene Ontology
Molecular Function
GO:0004844 uracil DNA N-glycosylase activity
GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds
Biological Process
GO:0006281 DNA repair
GO:0006284 base-excision repair

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Molecular Function
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Biological Process
External links
PDB RCSB:1ssp, PDBe:1ssp, PDBj:1ssp
PDBsum1ssp
PubMed9724657
UniProtP13051|UNG_HUMAN Uracil-DNA glycosylase (Gene Name=UNG)

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