Structure of PDB 1shh Chain E

Receptor sequence

>1shhE (length=257) Species: 9606 (Homo sapiens) [Search protein sequence]

IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPW
DKNFTENDLLVRIGKHSRTRYEANIEKISMLEKIYIHPRYNWRENLDRDI
ALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETWTA
NVGKGQPSVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDA
CEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWI
QKVIDQF

3D structure

PDB

1shh Molecular dissection of na+ binding to thrombin.

Chain

Resolution

1.55 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

3.4.21.5: thrombin.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	peptide	E	S36A Y76 A77A N78	S22 Y71 A73 N74
BS02	peptide	E	E23 G25 M26 P28 W29 D116 H119 P120 C122 Y134 K135 R137 N159 K202 P204 N205 R206 W207	E8 G10 M11 P13 W14 D113 H116 P117 C119 Y134 K135 R137 N164 K212 P214 N217 R218 W219
BS03	0G6	E	H57 Y60A W60D L99 D189 A190 S195 W215 G216	H43 Y47 W50 L96 D199 A200 S205 W227 G228

Gene Ontology

	Molecular Function
GO:0004252	serine-type endopeptidase activity
GO:0005509	calcium ion binding

	Biological Process
GO:0006508	proteolysis
GO:0007596	blood coagulation

View graph for
Molecular Function

View graph for
Biological Process

External links

PDB	RCSB:1shh, PDBe:1shh, PDBj:1shh
PDBsum	1shh
PubMed	15152000
UniProt	P00734\|THRB_HUMAN Prothrombin (Gene Name=F2)

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