Structure of PDB 1sgi Chain E

Receptor sequence
>1sgiE (length=250) Species: 9606 (Homo sapiens) [Search protein sequence]
IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPW
DKNFTENDLLVRIGKHSRTRYEANIEKISMLEKIYIHPRYNWRENLDRDI
ALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETGQP
SVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGG
PFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQF
3D structure
PDB1sgi Molecular dissection of na+ binding to thrombin.
ChainE
Resolution2.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.21.5: thrombin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide E E23 M26 P28 W29 D116 H119 P120 V121 C122 Y134 K135 G136 R137 N159 K186D M201 K202 R206 W207 E8 M11 P13 W14 D113 H116 P117 V118 C119 Y134 K135 G136 R137 N157 K189 M204 K205 R211 W212
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0005509 calcium ion binding
Biological Process
GO:0006508 proteolysis
GO:0007596 blood coagulation

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:1sgi, PDBe:1sgi, PDBj:1sgi
PDBsum1sgi
PubMed15152000
UniProtP00734|THRB_HUMAN Prothrombin (Gene Name=F2)

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