Structure of PDB 1rzt Chain E

Receptor sequence
>1rztE (length=326) Species: 9606 (Homo sapiens) [Search protein sequence]
TNHNLHITEKLEVLAKAYSVQGDKWRALGYAKAINALKSFHKPVTSYQEA
CSIPGIGKRMAEKIIEILESGHLRKLDHISESVPVLELFSNIWGAGTKTA
QMWYQQGFRSLEDIRSQASLTTQQAIGLKHYSDFLERMPREEATEIEQTV
QKAAQAFNSGLLCVACGSYRRGKATCGDVDVLITHPDGRSHRGIFSRLLD
SLRQEGFLTDDLVSQEENGQQQKYLGVCRLPGPGRRHRRLDIIVVPYSEF
ACALLYFTGSAHFNRSMRALAKTKGMSLSEHALSTAVVRNTHGCKVGPGR
VLPTPTEKDVFRLLGLPYREPAERDW
3D structure
PDB1rzt A structural solution for the DNA polymerase lambda-dependent repair of DNA gaps with minimal homology.
ChainE
Resolution2.1 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) D427 D429 D490
Catalytic site (residue number reindexed from 1) D178 D180 D241
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
4.2.99.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna E W274 T371 E465 E466 N467 Y505 R517 K521 W25 T122 E216 E217 N218 Y256 R268 K272
BS02 dna E G343 A344 G345 K347 T348 G94 A95 G96 K98 T99
BS03 dna E W274 R275 Y279 P303 G304 G306 R308 M309 K312 W25 R26 Y30 P54 G55 G57 R59 M60 K63
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
GO:0016779 nucleotidyltransferase activity
GO:0034061 DNA polymerase activity
Biological Process
GO:0006281 DNA repair

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:1rzt, PDBe:1rzt, PDBj:1rzt
PDBsum1rzt
PubMed14992725
UniProtQ9UGP5|DPOLL_HUMAN DNA polymerase lambda (Gene Name=POLL)

[Back to BioLiP]