Structure of PDB 1rnm Chain E

Receptor sequence

>1rnmE (length=124) Species: 9913 (Bos taurus)

KETAAAKFERQHMDSSTSAASSSNYCNQMMKSRNLTKDRCKPVNTFVHES
LADVQAVCSQKNVACKNGQTNCYQSYSTMSITDCRETGSSKYPNCAYKTT
QANKHIIVACEGNPYVPVHFDASV

3D structure

• PDB: 1rnm Structure of the Crystalline Complex of Bovine Pancreatic Ribonuclease A and Cytidylic Acid
• Chain: E
• Resolution: 2.0 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): H12 K41 H119 F120 D121
• Catalytic site (residue number reindexed from 1): H12 K41 H119 F120 D121
• Enzyme Commision number: 4.6.1.18: pancreatic ribonuclease.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	C5P	E	H12 V43 N44 T45 F120	H12 V43 N44 T45 F120	PDBbind-CN: -logKd/Ki=3.07,Ki=844.2uM

Gene Ontology

Molecular Function

• GO:0003676 nucleic acid binding
• GO:0004519 endonuclease activity
• GO:0004522 ribonuclease A activity
• GO:0004540 RNA nuclease activity
• GO:0005515 protein binding
• GO:0016829 lyase activity

Biological Process

• GO:0050830 defense response to Gram-positive bacterium

Cellular Component

• GO:0005576 extracellular region

External links

• PDB: RCSB:1rnm, PDBe:1rnm, PDBj:1rnm
• PDBsum: 1rnm
• UniProt: P61823|RNAS1_BOVIN Ribonuclease pancreatic (Gene Name=RNASE1)