Structure of PDB 1r8s Chain E

Receptor sequence
>1r8sE (length=187) Species: 9606 (Homo sapiens) [Search protein sequence]
NRKMAMGRKKFNMDPKKGIQFLVENELLQNTPEEIARFLYKGEGLNKTAI
GDYLGEREELNLAVLHAFVDLHEFTDLNLVQALRQFLWSFRLPGKAQKID
RMMEAFAQRYCLCNPGVFQSTDTCYVLSYSVIMLNTDLHNPNVRDKMGLE
RFVAMNRGINEGGDLPEELLRNLYDSIRNEPFKIPED
3D structure
PDB1r8s Structural snapshots of the mechanism and inhibition of a guanine nucleotide exchange factor
ChainE
Resolution1.46 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SO3 E P154 G155 K156 P93 G94 K95
Gene Ontology
Molecular Function
GO:0005085 guanyl-nucleotide exchange factor activity
Biological Process
GO:0032012 regulation of ARF protein signal transduction

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:1r8s, PDBe:1r8s, PDBj:1r8s
PDBsum1r8s
PubMed14654833
UniProtQ99418|CYH2_HUMAN Cytohesin-2 (Gene Name=CYTH2)

[Back to BioLiP]