Structure of PDB 1q3u Chain E

Receptor sequence

>1q3uE (length=321) Species: 10678 (Punavirus P1) [Search protein sequence]

DEVRKNLMDMFRDRQAFSEHTWKMLLSVCRSWAAWCKLNNRKWFPAEPED
VRDYLLYLQARGLAVKTIQQHLGQLNMLHRRSGLPRPSDSNAVSLVMRRI
RKENVDAGERAKQALAFERTDFDQVRSLMENSDRCQDIRNLAFLGIAYNT
LLRIAEIARIRVKDISRTDGGRMLIHIGRTKTLVSTAGVEKALSLGVTKL
VERWISVSGVADDPNNYLFCRVRKNGVAAPSATSQLSTRALEGIFEATHR
LIYGAKDDSGQRYLAWSGHSARVGAARDMARAGVSIPEIMQAGGWTNVNI
VMNYIRNLDSETGAMVRLLED

3D structure

PDB

1q3u Crystal structure of a wild-type Cre recombinase-loxP synapse reveals a novel spacer conformation suggesting an alternative mechanism for DNA cleavage activation

Chain

Resolution

2.9 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	dna	E	F37 S38 H40 T41 M97 A175 K244 N245 R259 E262 K276 R282 Y283 S287 G288 H289	F17 S18 H20 T21 M77 A155 K224 N225 R239 E242 K256 R262 Y263 S267 G268 H269
BS02	dna	E	K43 M44 S47 R50 R81 L83 A84 K86 T87 A131 K132 Q156 R159 T202 R241 V242 R243 K244 L256 S257 R259 R282 W315 Y324	K23 M24 S27 R30 R61 L63 A64 K66 T67 A111 K112 Q136 R139 T182 R221 V222 R223 K224 L236 S237 R239 R262 W295 Y304

Gene Ontology

	Molecular Function
GO:0003677	DNA binding

	Biological Process
GO:0006310	DNA recombination
GO:0015074	DNA integration

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Molecular Function

View graph for
Biological Process

External links

PDB	RCSB:1q3u, PDBe:1q3u, PDBj:1q3u
PDBsum	1q3u
PubMed	12954782
UniProt	P06956\|RECR_BPP1 Recombinase cre (Gene Name=cre)

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