Structure of PDB 1pjl Chain E

Receptor sequence

>1pjlE (length=551) Species: 9606 (Homo sapiens) [Search protein sequence]

EKGKPLMLNPRTNKGMAFTLQERQMLGLQGLLPPKIETQDIQALRFHRNL
KKMTSPLEKYIYIMGIQERNEKLFYRILQDDIESLMPIVYTPTVGLACSQ
YGHIFRRPKGLFISISDRGHVRSIVDNWPENHVKAVVVTDGERILGLGDL
GVYGMGIPVGKLCLYTACAGIRPDRCLPVCIDVGTDNIALLKDPFYMGLY
QKRDRTQQYDDLIDEFMKAITDRYGRNTLIQFEDFGNHNAFRFLRKYREK
YCTFNDDIQGTAAVALAGLLAAQKVISKPISEHKILFLGAGEAALGIANL
IVMSMVENGLSEQEAQKKIWMFDKYGLLVKGRKAKIDSYQEPFTHSAPES
IPDTFEDAVNILKPSTIIGVAGAGRLFTPDVIRAMASINERPVIFALSNP
TAQAECTAEEAYTLTEGRCLFASGSPFGPVKLTDGRVFTPGQGNNVYIFP
GVALAVILCNTRHISDSVFLEAAKALTSQLTDEELAQGRLYPPLANIQEV
SINIAIKVTEYLYANKMAFRYPEPEDKAKYVKERTWRSEYDSLLPDVYEW
P

3D structure

PDB

1pjl Potent and competitive inhibition of malic enzymes by lanthanide ions

Chain

Resolution

2.9 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

1.1.1.38: malate dehydrogenase (oxaloacetate-decarboxylating).

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	NAD	E	R4165 T4283 L4310 G4311 A4312 G4313 E4314 A4315 D4345 K4346 V4392 A4393 G4394 A4395 L4398 L4419 S4420 N4421 G4465 N4467	R143 T261 L288 G289 A290 G291 E292 A293 D323 K324 V370 A371 G372 A373 L376 L397 S398 N399 G443 N445
BS02	NAD	E	H4154 K4156 I4193 R4194 R4197 R4542 R4556	H132 K134 I171 R172 R175 R520 R534

Gene Ontology

	Molecular Function
GO:0004470	malic enzyme activity
GO:0004471	malate dehydrogenase (decarboxylating) (NAD+) activity
GO:0004473	malate dehydrogenase (decarboxylating) (NADP+) activity
GO:0008948	oxaloacetate decarboxylase activity
GO:0009055	electron transfer activity
GO:0016491	oxidoreductase activity
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0046872	metal ion binding
GO:0051287	NAD binding

	Biological Process
GO:0006090	pyruvate metabolic process
GO:0006108	malate metabolic process
GO:1902031	regulation of NADP metabolic process

	Cellular Component
GO:0005739	mitochondrion
GO:0005759	mitochondrial matrix
GO:0043231	intracellular membrane-bounded organelle

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:1pjl, PDBe:1pjl, PDBj:1pjl
PDBsum	1pjl
PubMed	10913357
UniProt	P23368\|MAOM_HUMAN NAD-dependent malic enzyme, mitochondrial (Gene Name=ME2)

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