Structure of PDB 1pek Chain E

Receptor sequence
>1pekE (length=279) Species: 37998 (Parengyodontium album) [Search protein sequence]
AAQTNAPWGLARISSTSPGTSTYYYDESAGQGSCVYVIDTGIEASHPEFE
GRAQMVKTYYYSSRDGNGHGTHCAGTVGSRTYGVVKKTQLFGVKVLDDNG
SGQYSTIIAGMDFVASDKNNRNCPKGVVASLSLGGGYSSSVNSAAARLQS
SGVMVAVAAGNNNADARNYSPASEPSVCTVGASDRYDRRSSFSNYGSVLD
IFGPGTSILSTWIGGSTRSISGTSMATPHVAGLAAYLMTLGKTTAASACR
YIADTANKGDLSNIPFGTVNLLAYNNYQA
3D structure
PDB1pek Structure of the complex of proteinase K with a substrate analogue hexapeptide inhibitor at 2.2-A resolution.
ChainE
Resolution2.2 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) S224
Catalytic site (residue number reindexed from 1) S224
Enzyme Commision number 3.4.21.64: peptidase K.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide E H69 L96 G100 S132 L133 G134 G135 A158 G160 N161 T223 S224 H69 L96 G100 S132 L133 G134 G135 A158 G160 N161 T223 S224
BS02 peptide E H69 N161 I220 S221 G222 S224 H69 N161 I220 S221 G222 S224
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0008236 serine-type peptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:1pek, PDBe:1pek, PDBj:1pek
PDBsum1pek
PubMed8340410
UniProtP06873|PRTK_PARAQ Proteinase K (Gene Name=PROK)

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