Structure of PDB 1ne7 Chain E

Receptor sequence
>1ne7E (length=274) Species: 9606 (Homo sapiens) [Search protein sequence]
MKLIILEHYSQASEWAAKYIRNRIIQFNPGPEKYFTLGLPTGSTPLGCYK
KLIEYYKNGDLSFKYVKTFNMDEYVGLPRDHPESYHSFMWNNFFKHIDIH
PENTHILDGNAVDLQAECDAFEEKIKAAGGIELFVGGIGPDGHIAFNEPG
SSLVSRTRVKTLAMDTILANARFFDGELTKVPTMALTVGVGTVMDAREVM
ILITGAHKAFALYKAIEEGVNHMWTVSAFQQHPRTVFVCDEDATLELKVK
TVKYFKGLMLVHNKLVDPLYSIKE
3D structure
PDB1ne7 Two mammalian glucosamine-6-phosphate deaminases: a structural and genetic study.
ChainE
Resolution1.75 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D72 D141 H143 E148
Catalytic site (residue number reindexed from 1) D72 D141 H143 E148
Enzyme Commision number 3.5.99.6: glucosamine-6-phosphate deaminase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GLC E F27 K33 F27 K33
BS02 16G E S151 S152 R158 V159 K160 T161 S151 S152 R158 V159 K160 T161
BS03 AGP E T41 T44 M71 D72 G137 H143 A145 K208 T41 T44 M71 D72 G137 H143 A145 K208
BS04 16G E M1 K2 H262 M1 K2 H262
Gene Ontology
Molecular Function
GO:0004342 glucosamine-6-phosphate deaminase activity
GO:0005515 protein binding
GO:0016787 hydrolase activity
GO:0016853 isomerase activity
GO:0042802 identical protein binding
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0006043 glucosamine catabolic process
GO:0006044 N-acetylglucosamine metabolic process
GO:0006046 N-acetylglucosamine catabolic process
GO:0006048 UDP-N-acetylglucosamine biosynthetic process
GO:0006091 generation of precursor metabolites and energy
GO:0007338 single fertilization
GO:0019262 N-acetylneuraminate catabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0070062 extracellular exosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1ne7, PDBe:1ne7, PDBj:1ne7
PDBsum1ne7
PubMed12965206
UniProtP46926|GNPI1_HUMAN Glucosamine-6-phosphate isomerase 1 (Gene Name=GNPDA1)

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