Structure of PDB 1n63 Chain E

Receptor sequence

>1n63E (length=795) Species: 504832 (Afipia carboxidovorans OM5) [Search protein sequence]

AEKLQGMGCKRKRVEDIRFTQGKGNYVDDVKLPGMLFGDFVRSSHAHARI
KSIDTSKAKALPGVFAVLTAADLKPLNLHYMPTLAGDVQAVLADEKVLFQ
NQEVAFVVAKDRYVAADAIELVEVDYEPLPVLVDPFKAMEPDAPLLREDI
KDKMTGAHGARKHHNHIFRWEIGDKEGTDATFAKAEVVSKDMFTYHRVHP
SPLETCQCVASMDKIKGELTLWGTFQAPHVIRTVVSLISGLPEHKIHVIA
PDIGGGFGNKVGAYSGYVCAVVASIVLGVPVKWVEDRMENLSTTSFARDY
HMTTELAATKDGKILAMRCHVLADHGAFDACADPSKWPAGFMNICTGSYD
MPVAHLAVDGVYTNKASGGVAYRCSFRVTEAVYAIERAIETLAQRLEMDS
ADLRIKNFIQPEQFPYMAPLGWEYDSGNYPLAMKKAMDTVGYHQLRAEQK
AKQEAFKRGETREIMGIGISFFTEIVGAGPSKNCDILGVSMFDSAEIRIH
PTGSVIARMGTKSQGQGHETTYAQIIATELGIPADDIMIEEGNTDTAPYG
LGTYGSRSTPTAGAATAVAARKIKAKAQMIAAHMLEVHEGDLEWDVDRFR
VKGLPEKFKTMKELAWASYNSPPPNLEPGLEAVNYYDPPNMTYPFGAYFC
IMDIDVDTGVAKTRRFYALDDCGTRINPMIIEGQVHGGLTEAFAVAMGQE
IRYDEQGNVLGASFMDFFLPTAVETPKWETDYTVTPSPHHPIGAKGVGES
PHVGGVPCFSNAVNDAYAFLNAGHIQMPHDAWRLWKVGEQLGLHV

3D structure

PDB

1n63 Catalysis at a dinuclear [CuSMo(=O)OH] cluster in a CO dehydrogenase resolved at 1.1-A resolution

Chain

Resolution

1.21 Å

3D
structure

Catalytic site residues are labeled in the structure
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Enzymatic activity

Catalytic site (original residue number in PDB)	Q240 V275 P352 I358 R387 C388 E763 S764
Catalytic site (residue number reindexed from 1)	Q226 V261 P338 I344 R373 C374 E749 S750
Enzyme Commision number	1.2.5.3: aerobic carbon monoxide dehydrogenase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	CUN	E	G272 A385 R387 C388 Y568 G569 E763	G258 A371 R373 C374 Y554 G555 E749
BS02	MCN	E	G270 F271 R387 Q528 G529 Q530 H532 T535 T567 Y568 S570 S572 T573 C686 T688 I690 I694 I695 Q698 K759 G760 V761 E763	G256 F257 R373 Q514 G515 Q516 H518 T521 T553 Y554 S556 S558 T559 C672 T674 I676 I680 I681 Q684 K745 G746 V747 E749

Gene Ontology

	Molecular Function
GO:0005506	iron ion binding
GO:0005507	copper ion binding
GO:0008805	carbon-monoxide oxygenase activity
GO:0016491	oxidoreductase activity
GO:0030151	molybdenum ion binding
GO:0043885	anaerobic carbon-monoxide dehydrogenase activity
GO:0046872	metal ion binding

View graph for
Molecular Function

External links

PDB	RCSB:1n63, PDBe:1n63, PDBj:1n63
PDBsum	1n63
PubMed	12475995
UniProt	P19919\|DCML_AFIC5 Carbon monoxide dehydrogenase large chain (Gene Name=coxL)

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