Structure of PDB 1lq8 Chain E

Receptor sequence

>1lq8E (length=329) Species: 9606 (Homo sapiens) [Search protein sequence]

RRDFTFDLYRALASAAPSQNIFFSPVSISMSLAMLSLGAGSSTKMQILEG
LGLNLQKSSEKELHRGFQQLLQELNQPRDGFQLSLGNALFTDLVVDLQDT
FVSAMKTLYLADTFPTNFRDSAGAMKQINDYVAKQTKGKIVDLLKNLDSN
AVVIMVNYIFFKAKWETSFNHKGTQEQDFYVTSETVVRVPMMSREDQYHY
LLDRNLSCRVVGVPYQGNATALFILPSEGKMQQVENGLSEKTLRKWLKMF
KKRQLELYLPKFSIEGSYQLEKVLPSLGISNVFTSHADLSGISNHSNIQV
SEMVHKAVVEVDESGTRAAAATGTIFTFR

3D structure

PDB

1lq8 Crystal Structure of Protein C Inhibitor Provides Insights into Hormone Binding and Heparin Activation

Chain

Resolution

2.4 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	E	F31 Y34 N45 I46 F47 F48 S49 V51 L95 L108 I184 F204 Y205 V206 V214 E220 T245 A246 L247 F248 I249 L250 P251 E253 M256 E260 L268 R278 Q279 L280 E281 Y283 F287 A343 A344	F6 Y9 N20 I21 F22 F23 S24 V26 L70 L83 I159 F179 Y180 V181 V189 E195 T220 A221 L222 F223 I224 L225 P226 E228 M231 E235 L243 R253 Q254 L255 E256 Y258 F262 A318 A319
BS02	peptide	E	L122 D124 V127 S128	L97 D99 V102 S103

Gene Ontology

	Molecular Function
GO:0004867	serine-type endopeptidase inhibitor activity

	Cellular Component
GO:0005615	extracellular space

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Molecular Function

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Cellular Component

External links

PDB	RCSB:1lq8, PDBe:1lq8, PDBj:1lq8
PDBsum	1lq8
PubMed	12575940
UniProt	P05154\|IPSP_HUMAN Plasma serine protease inhibitor (Gene Name=SERPINA5)

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