Structure of PDB 1k7l Chain E

Receptor sequence
>1k7lE (length=267) Species: 9606 (Homo sapiens) [Search protein sequence]
DLKSLAKRIYEAYLKNFNMNKVKARVILSGKASNNPPFVIHDMETLCMAE
KTLVAKLVANGIQNKEAEVRIFHCCQCTSVETVTELTEFAKAIPGFANLD
LNDQVTLLKYGVYEAIFAMLSSVMNKDGMLVAYGNGFITREFLKSLRKPF
CDIMEPKFDFAMKFNALELDDSDISLFVAAIICCGDRPGLLNVGHIEKMQ
EGIVHVLRLHLQSNHPDDIFLFPKLLQKMADLRQLVTEHAQLVQIIKKTE
SDAALHPLLQEIYRDMY
3D structure
PDB1k7l Structural determinants of ligand binding selectivity between the peroxisome proliferator-activated receptors.
ChainE
Resolution2.5 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide E K292 Q305 V306 K310 P458 L459 E462 K91 Q104 V105 K109 P257 L258 E261
BS02 544 E F273 C275 C276 S280 Y314 L321 V332 F351 I354 M355 H440 Y464 F72 C74 C75 S79 Y113 L120 V131 F150 I153 M154 H239 Y263 BindingDB: EC50=240nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:1k7l, PDBe:1k7l, PDBj:1k7l
PDBsum1k7l
PubMed11698662
UniProtQ07869|PPARA_HUMAN Peroxisome proliferator-activated receptor alpha (Gene Name=PPARA)

[Back to BioLiP]