Structure of PDB 1hag Chain E

Receptor sequence
>1hagE (length=295) Species: 9606 (Homo sapiens) [Search protein sequence]
TFGSGEADCGLRPLFEKKSLEDKTERELLESYIDGRIVEGSDAEIGMSPW
QVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTENDLLVRIG
KHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDIALMKLKKPVAFSDY
IHPVCLPDRETAASLLQAGYKGRVTGWGNLKETWTANVGKGQPSVLQVVN
LPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGGPFVMKSP
FNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQFGE
3D structure
PDB1hag The isomorphous structures of prethrombin2, hirugen-, and PPACK-thrombin: changes accompanying activation and exosite binding to thrombin.
ChainE
Resolution2.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.21.5: thrombin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide E F34 K36 L65 T74 R75 Y76 K81 I82 M84 F55 K57 L96 T105 R106 Y107 K113 I114 M116
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0005509 calcium ion binding
Biological Process
GO:0006508 proteolysis
GO:0007596 blood coagulation
Cellular Component
GO:0005576 extracellular region

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1hag, PDBe:1hag, PDBj:1hag
PDBsum1hag
PubMed7756983
UniProtP00734|THRB_HUMAN Prothrombin (Gene Name=F2)

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