Structure of PDB 1ere Chain E

Receptor sequence
>1ereE (length=235) Species: 9606 (Homo sapiens) [Search protein sequence]
SLALSLTADQMVSALLDAEPPILYSEFSEASMMGLLTNLADRELVHMINW
AKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLL
DRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYT
FTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSH
IRHMSNKGMEHLYSMKCKNVVPLYDLLLEMLDAHR
3D structure
PDB1ere Molecular basis of agonism and antagonism in the oestrogen receptor.
ChainE
Resolution3.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 EST E E353 F404 H524 L525 E43 F94 H211 L212 BindingDB: IC50=1.3nM,Kd=0.2nM,EC50=0.75nM,Ki=0.21nM
External links
PDB RCSB:1ere, PDBe:1ere, PDBj:1ere
PDBsum1ere
PubMed9338790
UniProtP03372|ESR1_HUMAN Estrogen receptor (Gene Name=ESR1)

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