Structure of PDB 1egh Chain E

Receptor sequence
>1eghE (length=152) Species: 562 (Escherichia coli) [Search protein sequence]
MELTTRTLPARKHIALVAHDHCKQMLMSWVERHQPLLEQHVLYATGTTGN
LISRATGMNVNAMLSGPMGGDQQVGALISEGKIDVLIFFWDPLNAVPHDP
DVKALLRLATVWNIPVATNVATADFIIQSPHFNDAVDILIPDYQRYLADR
LK
3D structure
PDB1egh Mirroring perfection: the structure of methylglyoxal synthase complexed with the competitive inhibitor 2-phosphoglycolate.
ChainE
Resolution2.0 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H19 G66 D71 D91 H98 D101 R107
Catalytic site (residue number reindexed from 1) H19 G66 D71 D91 H98 D101 R107
Enzyme Commision number 4.2.3.3: methylglyoxal synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PGA E V17 H19 K23 T45 T47 T48 S65 G66 D71 H98 V17 H19 K23 T45 T47 T48 S65 G66 D71 H98 MOAD: Ki=2uM
Gene Ontology
Molecular Function
GO:0008929 methylglyoxal synthase activity
GO:0016829 lyase activity
GO:0042802 identical protein binding
Biological Process
GO:0019242 methylglyoxal biosynthetic process
GO:0034214 protein hexamerization
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Biological Process
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Cellular Component
External links
PDB RCSB:1egh, PDBe:1egh, PDBj:1egh
PDBsum1egh
PubMed10715115
UniProtP0A731|MGSA_ECOLI Methylglyoxal synthase (Gene Name=mgsA)

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