Structure of PDB 1czi Chain E

Receptor sequence
>1cziE (length=323) Species: 9913 (Bos taurus) [Search protein sequence]
GEVASVPLTNYLDSQYFGKIYLGTPPQEFTVLFDTGSSDFWVPSIYCKSN
ACKNHQRFDPRKSSTFQNLGKPLSIHYGTGSMQGILGYDTVTVSNIVDIQ
QTVGLSTQEPGDVFTYAEFDGILGMAYPSLASEYSIPVFDNMMNRHLVAQ
DLFSVYMDRNGQESMLTLGAIDPSYYTGSLHWVPVTVQQYWQFTVDSVTI
SGVVVACEGGCQAILDTGTSKLVGPSSDILNIQQAIGATQNQYGEFDIDC
DNLSYMPTVVFEINGKMYPLTPSAYTSQDQGFCTSGFQSENHSQKWILGD
VFIREYYSVFDRANNLVGLAKAI
3D structure
PDB1czi A 2.3 A resolution structure of chymosin complexed with a reduced bond inhibitor shows that the active site beta-hairpin flap is rearranged when compared with the native crystal structure.
ChainE
Resolution2.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.23.4: chymosin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide E Q13 D32 Y75 G76 T77 V111 F112 Y114 A115 D215 G217 S219 K220 Q287 Q15 D34 Y77 G78 T79 V113 F114 Y116 A117 D216 G218 S220 K221 Q288
Gene Ontology
Molecular Function
GO:0004190 aspartic-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:1czi, PDBe:1czi, PDBj:1czi
PDBsum1czi
PubMed9862200
UniProtP00794|CHYM_BOVIN Chymosin (Gene Name=CYM)

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