Structure of PDB 1ca9 Chain E

Receptor sequence
>1ca9E (length=186) Species: 9606 (Homo sapiens) [Search protein sequence]
ALSSKVQQLERSIGLKDLAMADLEQKVLEMEASTYDGVFIWKISDFARKR
QEAVAGRIPAIFSPAFYTSRYGYKMCLRIYLNGDGTGRGTHLSLFFVVMK
GPNDALLRWPFNQKVTLMLLDQNNREHVIDAFRPDVTSSSFQRPVNDMNI
ASGCPLFCPVSKMEAKNSYVRDDAIFIKAIVDLTGL
3D structure
PDB1ca9 Structural basis for self-association and receptor recognition of human TRAF2.
ChainE
Resolution2.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide E E367 R372 I373 E52 R57 I58
Gene Ontology
Molecular Function
GO:0004842 ubiquitin-protein transferase activity
GO:0005164 tumor necrosis factor receptor binding
Biological Process
GO:0007250 activation of NF-kappaB-inducing kinase activity
GO:0033209 tumor necrosis factor-mediated signaling pathway
GO:0042981 regulation of apoptotic process
GO:0046328 regulation of JNK cascade
GO:0051865 protein autoubiquitination

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:1ca9, PDBe:1ca9, PDBj:1ca9
PDBsum1ca9
PubMed10206649
UniProtQ12933|TRAF2_HUMAN TNF receptor-associated factor 2 (Gene Name=TRAF2)

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