/var/www/html/BioLiP/script/receptor1 /var/www/html/BioLiP/output/7yl0E.pdb.gz -
ATOM 1 N LYS R 1 198.459 142.672 134.936 1.00186.14 N
ATOM 2 CA LYS R 1 197.368 143.227 134.145 1.00186.14 C
ATOM 3 C LYS R 1 197.032 144.645 134.582 1.00186.14 C
ATOM 4 O LYS R 1 197.606 145.594 134.076 1.00186.14 O
ATOM 5 CB LYS R 1 196.132 142.336 134.231 1.00186.14 C
ATOM 6 CG LYS R 1 196.315 140.982 133.569 1.00186.14 C
ATOM 7 CD LYS R 1 195.004 140.225 133.464 1.00186.14 C
ATOM 8 CE LYS R 1 195.177 138.949 132.657 1.00186.14 C
ATOM 9 NZ LYS R 1 193.910 138.176 132.551 1.00186.14 N
ATOM 10 N CYS R 2 196.113 144.764 135.528 1.00190.10 N
ATOM 11 CA CYS R 2 195.670 146.074 135.970 1.00190.10 C
ATOM 12 C CYS R 2 196.473 146.542 137.197 1.00190.10 C
ATOM 13 O CYS R 2 195.916 146.652 138.288 1.00190.10 O
ATOM 14 CB CYS R 2 194.148 145.996 136.225 1.00190.10 C
ATOM 15 SG CYS R 2 193.232 144.890 135.071 1.00190.10 S
ATOM 16 N ASN R 3 197.773 146.823 137.028 1.00192.23 N
ATOM 17 CA ASN R 3 198.613 147.224 138.133 1.00192.23 C
ATOM 18 C ASN R 3 198.159 148.531 138.714 1.00192.23 C
ATOM 19 O ASN R 3 198.102 148.624 139.911 1.00192.23 O
ATOM 20 CB ASN R 3 200.066 147.361 137.678 1.00192.23 C
ATOM 21 CG ASN R 3 200.721 146.024 137.380 1.00192.23 C
ATOM 22 OD1 ASN R 3 200.301 144.978 137.875 1.00192.23 O
ATOM 23 ND2 ASN R 3 201.760 146.055 136.557 1.00192.23 N
ATOM 24 N THR R 4 197.771 149.512 137.897 1.00191.05 N
ATOM 25 CA THR R 4 197.469 150.851 138.413 1.00191.05 C
ATOM 26 C THR R 4 196.051 151.211 138.875 1.00191.05 C
ATOM 27 O THR R 4 195.865 151.457 140.068 1.00191.05 O
ATOM 28 CB THR R 4 197.932 151.930 137.417 1.00 30.00 C
ATOM 29 OG1 THR R 4 199.351 151.831 137.226 1.00 30.00 O
ATOM 30 CG2 THR R 4 197.590 153.320 137.929 1.00 30.00 C
ATOM 31 N ALA R 5 195.049 151.219 137.993 1.00184.18 N
ATOM 32 CA ALA R 5 193.720 151.668 138.455 1.00184.18 C
ATOM 33 C ALA R 5 192.437 151.259 137.751 1.00184.18 C
ATOM 34 O ALA R 5 192.459 150.957 136.559 1.00184.18 O
ATOM 35 CB ALA R 5 193.727 153.188 138.592 1.00184.18 C
ATOM 36 N THR R 6 191.334 151.198 138.497 1.00176.83 N
ATOM 37 CA THR R 6 189.995 150.986 137.927 1.00176.83 C
ATOM 38 C THR R 6 189.760 149.848 136.929 1.00176.83 C
ATOM 39 O THR R 6 189.176 150.079 135.870 1.00176.83 O
ATOM 40 CB THR R 6 189.458 152.292 137.301 1.00176.83 C
ATOM 41 OG1 THR R 6 189.711 153.389 138.186 1.00176.83 O
ATOM 42 CG2 THR R 6 187.962 152.188 137.044 1.00176.83 C
ATOM 43 N CYS R 7 190.180 148.647 137.276 1.00173.53 N
ATOM 44 CA CYS R 7 189.990 147.530 136.383 1.00173.53 C
ATOM 45 C CYS R 7 188.883 146.652 136.899 1.00173.53 C
ATOM 46 O CYS R 7 188.964 146.146 138.018 1.00173.53 O
ATOM 47 CB CYS R 7 191.267 146.730 136.322 1.00173.53 C
ATOM 48 SG CYS R 7 191.218 145.271 135.268 1.00173.53 S
ATOM 49 N ALA R 8 187.842 146.452 136.101 1.00151.59 N
ATOM 50 CA ALA R 8 186.821 145.528 136.561 1.00151.59 C
ATOM 51 C ALA R 8 186.680 144.365 135.602 1.00151.59 C
ATOM 52 O ALA R 8 186.844 144.548 134.396 1.00151.59 O
ATOM 53 CB ALA R 8 185.501 146.249 136.699 1.00151.59 C
ATOM 54 N THR R 9 186.378 143.183 136.122 1.00140.87 N
ATOM 55 CA THR R 9 186.252 141.997 135.287 1.00140.87 C
ATOM 56 C THR R 9 185.175 141.065 135.755 1.00140.87 C
ATOM 57 O THR R 9 185.181 140.644 136.905 1.00140.87 O
ATOM 58 CB THR R 9 187.548 141.170 135.307 1.00140.87 C
ATOM 59 OG1 THR R 9 188.625 141.963 134.791 1.00140.87 O
ATOM 60 CG2 THR R 9 187.406 139.912 134.466 1.00140.87 C
ATOM 61 N GLN R 10 184.248 140.724 134.878 1.00127.98 N
ATOM 62 CA GLN R 10 183.257 139.730 135.238 1.00127.98 C
ATOM 63 C GLN R 10 183.620 138.516 134.418 1.00127.98 C
ATOM 64 O GLN R 10 183.739 138.599 133.197 1.00127.98 O
ATOM 65 CB GLN R 10 181.845 140.199 134.900 1.00127.98 C
ATOM 66 CG GLN R 10 180.765 139.166 135.160 1.00127.98 C
ATOM 67 CD GLN R 10 179.380 139.775 135.169 1.00127.98 C
ATOM 68 OE1 GLN R 10 179.226 140.990 135.284 1.00127.98 O
ATOM 69 NE2 GLN R 10 178.361 138.933 135.054 1.00127.98 N
ATOM 70 N ARG R 11 183.806 137.383 135.080 1.00126.76 N
ATOM 71 CA ARG R 11 184.201 136.165 134.398 1.00126.76 C
ATOM 72 C ARG R 11 183.060 135.174 134.517 1.00126.76 C
ATOM 73 O ARG R 11 182.724 134.773 135.622 1.00126.76 O
ATOM 74 CB ARG R 11 185.448 135.644 135.092 1.00126.76 C
ATOM 75 CG ARG R 11 186.049 134.363 134.547 1.00126.76 C
ATOM 76 CD ARG R 11 187.275 134.014 135.376 1.00126.76 C
ATOM 77 NE ARG R 11 187.843 132.712 135.044 1.00126.76 N
ATOM 78 CZ ARG R 11 188.906 132.195 135.651 1.00126.76 C
ATOM 79 NH1 ARG R 11 189.512 132.870 136.617 1.00126.76 N
ATOM 80 NH2 ARG R 11 189.365 131.003 135.295 1.00126.76 N
ATOM 81 N LEU R 12 182.420 134.854 133.405 1.00115.44 N
ATOM 82 CA LEU R 12 181.335 133.908 133.480 1.00115.44 C
ATOM 83 C LEU R 12 181.554 132.719 132.570 1.00115.44 C
ATOM 84 O LEU R 12 181.667 132.858 131.352 1.00115.44 O
ATOM 85 CB LEU R 12 180.008 134.591 133.142 1.00115.44 C
ATOM 86 CG LEU R 12 178.735 133.760 133.318 1.00115.44 C
ATOM 87 CD1 LEU R 12 177.498 134.628 133.144 1.00115.44 C
ATOM 88 CD2 LEU R 12 178.709 132.584 132.352 1.00115.44 C
ATOM 89 N ALA R 13 181.608 131.544 133.178 1.00114.35 N
ATOM 90 CA ALA R 13 181.703 130.303 132.418 1.00114.35 C
ATOM 91 C ALA R 13 180.461 129.479 132.701 1.00114.35 C
ATOM 92 O ALA R 13 180.288 128.975 133.814 1.00114.35 O
ATOM 93 CB ALA R 13 182.968 129.525 132.794 1.00114.35 C
ATOM 94 N ASN R 14 179.598 129.361 131.693 1.00113.22 N
ATOM 95 CA ASN R 14 178.362 128.611 131.851 1.00113.22 C
ATOM 96 C ASN R 14 178.345 127.392 130.965 1.00113.22 C
ATOM 97 O ASN R 14 178.554 127.499 129.767 1.00113.22 O
ATOM 98 CB ASN R 14 177.153 129.495 131.565 1.00113.22 C
ATOM 99 CG ASN R 14 175.836 128.809 131.864 1.00113.22 C
ATOM 100 OD1 ASN R 14 174.820 129.102 131.237 1.00113.22 O
ATOM 101 ND2 ASN R 14 175.845 127.894 132.820 1.00113.22 N
ATOM 102 N PHE R 15 178.118 126.231 131.543 1.00111.78 N
ATOM 103 CA PHE R 15 178.056 124.969 130.823 1.00111.78 C
ATOM 104 C PHE R 15 176.766 124.268 131.206 1.00111.78 C
ATOM 105 O PHE R 15 176.501 124.054 132.391 1.00111.78 O
ATOM 106 CB PHE R 15 179.257 124.073 131.151 1.00111.78 C
ATOM 107 CG PHE R 15 180.584 124.780 131.093 1.00111.78 C
ATOM 108 CD1 PHE R 15 181.018 125.559 132.154 1.00111.78 C
ATOM 109 CD2 PHE R 15 181.415 124.639 129.994 1.00111.78 C
ATOM 110 CE1 PHE R 15 182.239 126.202 132.107 1.00111.78 C
ATOM 111 CE2 PHE R 15 182.642 125.279 129.949 1.00111.78 C
ATOM 112 CZ PHE R 15 183.052 126.062 131.006 1.00111.78 C
ATOM 113 N LEU R 16 175.974 123.914 130.199 1.00 96.46 N
ATOM 114 CA LEU R 16 174.698 123.253 130.426 1.00 96.46 C
ATOM 115 C LEU R 16 174.680 121.975 129.603 1.00 96.46 C
ATOM 116 O LEU R 16 175.050 121.996 128.435 1.00 96.46 O
ATOM 117 CB LEU R 16 173.576 124.171 129.958 1.00 96.46 C
ATOM 118 CG LEU R 16 172.147 123.976 130.452 1.00 96.46 C
ATOM 119 CD1 LEU R 16 171.453 125.325 130.402 1.00 96.46 C
ATOM 120 CD2 LEU R 16 171.408 122.973 129.581 1.00 96.46 C
ATOM 121 N VAL R 17 174.261 120.867 130.204 1.00 93.92 N
ATOM 122 CA VAL R 17 174.203 119.595 129.498 1.00 93.92 C
ATOM 123 C VAL R 17 172.847 118.957 129.702 1.00 93.92 C
ATOM 124 O VAL R 17 172.625 118.312 130.706 1.00 93.92 O
ATOM 125 CB VAL R 17 175.238 118.618 130.062 1.00 93.92 C
ATOM 126 CG1 VAL R 17 175.259 117.323 129.261 1.00 93.92 C
ATOM 127 CG2 VAL R 17 176.623 119.242 130.111 1.00 93.92 C
ATOM 128 N HIS R 18 171.936 119.121 128.760 1.00 93.10 N
ATOM 129 CA HIS R 18 170.652 118.473 128.876 1.00 93.10 C
ATOM 130 C HIS R 18 170.739 117.244 128.042 1.00 93.10 C
ATOM 131 O HIS R 18 170.984 117.321 126.855 1.00 93.10 O
ATOM 132 CB HIS R 18 169.548 119.364 128.331 1.00 93.10 C
ATOM 133 CG HIS R 18 168.191 118.730 128.331 1.00 93.10 C
ATOM 134 ND1 HIS R 18 167.223 119.050 129.254 1.00 93.10 N
ATOM 135 CD2 HIS R 18 167.636 117.808 127.506 1.00 93.10 C
ATOM 136 CE1 HIS R 18 166.133 118.350 129.006 1.00 93.10 C
ATOM 137 NE2 HIS R 18 166.357 117.587 127.952 1.00 93.10 N
ATOM 138 N SER R 19 170.532 116.092 128.640 1.00 95.21 N
ATOM 139 CA SER R 19 170.559 114.867 127.889 1.00 95.21 C
ATOM 140 C SER R 19 169.383 114.026 128.250 1.00 95.21 C
ATOM 141 O SER R 19 169.138 113.787 129.417 1.00 95.21 O
ATOM 142 CB SER R 19 171.826 114.097 128.185 1.00 95.21 C
ATOM 143 OG SER R 19 171.773 112.810 127.602 1.00 95.21 O
ATOM 144 N SER R 20 168.639 113.567 127.262 1.00 97.57 N
ATOM 145 CA SER R 20 167.559 112.663 127.565 1.00 97.57 C
ATOM 146 C SER R 20 167.787 111.414 126.780 1.00 97.57 C
ATOM 147 O SER R 20 167.815 111.459 125.567 1.00 97.57 O
ATOM 148 CB SER R 20 166.225 113.267 127.165 1.00 97.57 C
ATOM 149 OG SER R 20 165.203 112.290 127.198 1.00 97.57 O
ATOM 150 N ASN R 21 167.978 110.282 127.434 1.00 97.79 N
ATOM 151 CA ASN R 21 168.096 109.025 126.718 1.00 97.79 C
ATOM 152 C ASN R 21 166.845 108.281 127.058 1.00 97.79 C
ATOM 153 O ASN R 21 166.707 107.805 128.171 1.00 97.79 O
ATOM 154 CB ASN R 21 169.317 108.245 127.166 1.00 97.79 C
ATOM 155 CG ASN R 21 170.612 108.977 126.889 1.00 97.79 C
ATOM 156 OD1 ASN R 21 171.630 108.705 127.521 1.00 97.79 O
ATOM 157 ND2 ASN R 21 170.586 109.905 125.943 1.00 97.79 N
ATOM 158 N ASN R 22 165.913 108.209 126.129 1.00 96.40 N
ATOM 159 CA ASN R 22 164.643 107.577 126.410 1.00 96.40 C
ATOM 160 C ASN R 22 164.603 106.184 125.834 1.00 96.40 C
ATOM 161 O ASN R 22 164.239 106.008 124.681 1.00 96.40 O
ATOM 162 CB ASN R 22 163.535 108.443 125.829 1.00 96.40 C
ATOM 163 CG ASN R 22 162.206 107.739 125.743 1.00 96.40 C
ATOM 164 OD1 ASN R 22 161.495 107.874 124.758 1.00 96.40 O
ATOM 165 ND2 ASN R 22 161.875 106.975 126.754 1.00 96.40 N
ATOM 166 N PHE R 23 164.997 105.180 126.602 1.00100.58 N
ATOM 167 CA PHE R 23 164.853 103.834 126.066 1.00100.58 C
ATOM 168 C PHE R 23 163.480 103.328 126.417 1.00100.58 C
ATOM 169 O PHE R 23 163.369 102.307 127.078 1.00100.58 O
ATOM 170 CB PHE R 23 165.843 102.871 126.706 1.00100.58 C
ATOM 171 CG PHE R 23 167.282 103.179 126.436 1.00100.58 C
ATOM 172 CD1 PHE R 23 167.922 104.217 127.090 1.00100.58 C
ATOM 173 CD2 PHE R 23 168.012 102.395 125.568 1.00100.58 C
ATOM 174 CE1 PHE R 23 169.251 104.490 126.851 1.00100.58 C
ATOM 175 CE2 PHE R 23 169.345 102.658 125.327 1.00100.58 C
ATOM 176 CZ PHE R 23 169.966 103.708 125.967 1.00100.58 C
ATOM 177 N GLY R 24 162.429 103.991 125.978 1.00101.55 N
ATOM 178 CA GLY R 24 161.105 103.585 126.406 1.00101.55 C
ATOM 179 C GLY R 24 160.041 104.527 125.919 1.00101.55 C
ATOM 180 O GLY R 24 160.269 105.291 124.995 1.00101.55 O
ATOM 181 N ALA R 25 158.876 104.502 126.547 1.00 99.93 N
ATOM 182 CA ALA R 25 157.775 105.322 126.070 1.00 99.93 C
ATOM 183 C ALA R 25 157.523 106.560 126.887 1.00 99.93 C
ATOM 184 O ALA R 25 157.334 106.480 128.084 1.00 99.93 O
ATOM 185 CB ALA R 25 156.514 104.492 126.013 1.00 99.93 C
ATOM 186 N ILE R 26 157.524 107.716 126.236 1.00 94.15 N
ATOM 187 CA ILE R 26 157.206 108.967 126.903 1.00 94.15 C
ATOM 188 C ILE R 26 155.968 109.437 126.197 1.00 94.15 C
ATOM 189 O ILE R 26 155.943 109.478 124.982 1.00 94.15 O
ATOM 190 CB ILE R 26 158.259 110.052 126.647 1.00 94.15 C
ATOM 191 CG1 ILE R 26 159.629 109.635 127.154 1.00 94.15 C
ATOM 192 CG2 ILE R 26 157.850 111.372 127.282 1.00 94.15 C
ATOM 193 CD1 ILE R 26 160.642 110.753 127.082 1.00 94.15 C
ATOM 194 N LEU R 27 154.930 109.784 126.927 1.00 96.67 N
ATOM 195 CA LEU R 27 153.751 110.324 126.296 1.00 96.67 C
ATOM 196 C LEU R 27 153.485 111.647 126.951 1.00 96.67 C
ATOM 197 O LEU R 27 153.504 111.747 128.165 1.00 96.67 O
ATOM 198 CB LEU R 27 152.576 109.377 126.496 1.00 96.67 C
ATOM 199 CG LEU R 27 151.214 109.615 125.839 1.00 96.67 C
ATOM 200 CD1 LEU R 27 150.499 108.286 125.652 1.00 96.67 C
ATOM 201 CD2 LEU R 27 150.333 110.586 126.610 1.00 96.67 C
ATOM 202 N SER R 28 153.194 112.664 126.161 1.00 94.85 N
ATOM 203 CA SER R 28 152.948 113.982 126.709 1.00 94.85 C
ATOM 204 C SER R 28 151.856 114.718 125.989 1.00 94.85 C
ATOM 205 O SER R 28 151.786 114.680 124.775 1.00 94.85 O
ATOM 206 CB SER R 28 154.212 114.818 126.654 1.00 94.85 C
ATOM 207 OG SER R 28 153.936 116.160 127.001 1.00 94.85 O
ATOM 208 N SER R 29 150.999 115.405 126.721 1.00 93.36 N
ATOM 209 CA SER R 29 149.953 116.188 126.093 1.00 93.36 C
ATOM 210 C SER R 29 149.888 117.551 126.719 1.00 93.36 C
ATOM 211 O SER R 29 149.766 117.665 127.922 1.00 93.36 O
ATOM 212 CB SER R 29 148.606 115.505 126.252 1.00 93.36 C
ATOM 213 OG SER R 29 147.562 116.362 125.832 1.00 93.36 O
ATOM 214 N THR R 30 149.963 118.598 125.913 1.00 87.13 N
ATOM 215 CA THR R 30 149.825 119.932 126.455 1.00 87.13 C
ATOM 216 C THR R 30 148.614 120.535 125.801 1.00 87.13 C
ATOM 217 O THR R 30 148.600 120.706 124.599 1.00 87.13 O
ATOM 218 CB THR R 30 151.048 120.787 126.127 1.00 87.13 C
ATOM 219 OG1 THR R 30 152.236 120.076 126.496 1.00 87.13 O
ATOM 220 CG2 THR R 30 150.998 122.102 126.878 1.00 87.13 C
ATOM 221 N ASN R 31 147.575 120.838 126.558 1.00 82.15 N
ATOM 222 CA ASN R 31 146.367 121.365 125.967 1.00 82.15 C
ATOM 223 C ASN R 31 146.107 122.746 126.512 1.00 82.15 C
ATOM 224 O ASN R 31 145.350 122.903 127.452 1.00 82.15 O
ATOM 225 CB ASN R 31 145.159 120.487 126.267 1.00 82.15 C
ATOM 226 CG ASN R 31 145.270 119.097 125.682 1.00 82.15 C
ATOM 227 OD1 ASN R 31 144.532 118.197 126.078 1.00 82.15 O
ATOM 228 ND2 ASN R 31 146.176 118.909 124.737 1.00 82.15 N
ATOM 229 N VAL R 32 146.712 123.762 125.919 1.00 77.91 N
ATOM 230 CA VAL R 32 146.548 125.101 126.448 1.00 77.91 C
ATOM 231 C VAL R 32 145.437 125.855 125.751 1.00 77.91 C
ATOM 232 O VAL R 32 145.533 126.147 124.575 1.00 77.91 O
ATOM 233 CB VAL R 32 147.792 125.928 126.207 1.00 77.91 C
ATOM 234 CG1 VAL R 32 147.520 127.370 126.592 1.00 77.91 C
ATOM 235 CG2 VAL R 32 148.975 125.341 126.956 1.00 77.91 C
ATOM 236 N GLY R 33 144.389 126.198 126.497 1.00 75.92 N
ATOM 237 CA GLY R 33 143.279 126.948 125.929 1.00 75.92 C
ATOM 238 C GLY R 33 142.333 126.062 125.157 1.00 75.92 C
ATOM 239 O GLY R 33 141.268 126.508 124.731 1.00 75.92 O
ATOM 240 N SER R 34 142.708 124.802 124.977 1.00 76.59 N
ATOM 241 CA SER R 34 141.891 123.887 124.234 1.00 76.59 C
ATOM 242 C SER R 34 140.656 123.567 124.993 1.00 76.59 C
ATOM 243 O SER R 34 140.617 123.772 126.156 1.00 76.59 O
ATOM 244 CB SER R 34 142.668 122.615 123.993 1.00 76.59 C
ATOM 245 OG SER R 34 141.861 121.642 123.361 1.00 76.59 O
ATOM 246 N ASN R 35 139.609 123.117 124.349 1.00 79.18 N
ATOM 247 CA ASN R 35 138.449 122.690 125.089 1.00 79.18 C
ATOM 248 C ASN R 35 137.889 121.490 124.402 1.00 79.18 C
ATOM 249 O ASN R 35 138.045 121.347 123.217 1.00 79.18 O
ATOM 250 CB ASN R 35 137.400 123.783 125.138 1.00 79.18 C
ATOM 251 CG ASN R 35 137.907 125.054 125.774 1.00 79.18 C
ATOM 252 OD1 ASN R 35 138.099 126.066 125.114 1.00 79.18 O
ATOM 253 ND2 ASN R 35 138.151 125.001 127.062 1.00 79.18 N
ATOM 254 N THR R 36 137.241 120.607 125.127 1.00 87.70 N
ATOM 255 CA THR R 36 136.600 119.483 124.492 1.00 87.70 C
ATOM 256 C THR R 36 135.146 119.539 124.840 1.00 87.70 C
ATOM 257 O THR R 36 134.801 119.628 126.003 1.00 87.70 O
ATOM 258 CB THR R 36 137.176 118.164 124.990 1.00 87.70 C
ATOM 259 OG1 THR R 36 138.601 118.187 124.858 1.00 87.70 O
ATOM 260 CG2 THR R 36 136.619 117.001 124.197 1.00 87.70 C
ATOM 261 N TYR R 37 134.098 119.698 124.259 1.00 20.00 N
ATOM 262 CA TYR R 37 132.630 119.681 124.264 1.00 20.00 C
ATOM 263 C TYR R 37 132.141 118.300 123.913 1.00 20.00 C
ATOM 264 O TYR R 37 132.802 117.591 123.185 1.00 20.00 O
ATOM 265 CB TYR R 37 132.106 120.686 123.238 1.00 20.00 C
ATOM 266 CG TYR R 37 132.464 122.082 123.671 1.00 20.00 C
ATOM 267 CD1 TYR R 37 133.742 122.565 123.453 1.00 20.00 C
ATOM 268 CD2 TYR R 37 131.515 122.882 124.281 1.00 20.00 C
ATOM 269 CE1 TYR R 37 134.072 123.847 123.852 1.00 20.00 C
ATOM 270 CE2 TYR R 37 131.842 124.160 124.683 1.00 20.00 C
ATOM 271 OH TYR R 37 133.447 125.909 124.860 1.00 20.00 O
ATOM 272 CZ TYR R 37 133.124 124.648 124.467 1.00 20.00 C
ATOM 273 NXT TYR R 37 130.971 117.853 124.408 1.00 20.00 N
TER