Structure of PDB 4u26 Chain DW

Receptor sequence

>4u26DW (length=75) Species: 83333 (Escherichia coli K-12)

RNGRDSEAKRLGVKRFGGESVLAGSIIVRQRGTKFHAGANVGCGRDHTLF
AKADGKVKFEVKGPKNRKFISIEAE

3D structure

• PDB: 4u26 Synergy of streptogramin antibiotics occurs independently of their effects on translation.
• Chain: DW
• Resolution: 2.8 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	DW	N12 R14 D15 S16 E17 A18 K19 R20 K24 R25 F26 G27 G28 E29 A33 G34 S35 I36 R39 R41 T43 F45 G54 R55 D56 H57 F60 F69 R77 K78	N2 R4 D5 S6 E7 A8 K9 R10 K14 R15 F16 G17 G18 E19 A23 G24 S25 I26 R29 R31 T33 F35 G44 R45 D46 H47 F50 F59 R67 K68
BS02	rna	DW	K72 G73 P74 N76	K62 G63 P64 N66

Gene Ontology

Molecular Function

• GO:0003735 structural constituent of ribosome

Biological Process

• GO:0006412 translation

Cellular Component

• GO:0005840 ribosome

External links

• PDB: RCSB:4u26, PDBe:4u26, PDBj:4u26
• PDBsum: 4u26
• PubMed: 24957822
• UniProt: P0A7L8|RL27_ECOLI Large ribosomal subunit protein bL27 (Gene Name=rpmA)