Structure of PDB 8cq7 Chain DS

Receptor sequence

>8cq7DS (length=70) Species: 5476 (Candida albicans)

RKKKVYTTPKKIKHKHRKHKLAVLTYYKVDNEGNVERLRRECPAPTCGAG
IFMANMKDRQYCGKCHLTLK

3D structure

• PDB: 8cq7 Drug-induced rotational movement of the ribosome is a key factor for read-through enhancement
• Chain: DS
• Resolution: 3.2 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	DS	R122 T128 T129 K131 K132 K134 H135 H137 R138 K141 L142 Y147 R160 F173 M174 A175 M177 R180 Y182 C183 G184 K185 H187 T189	R1 T7 T8 K10 K11 K13 H14 H16 R17 K20 L21 Y26 R39 F52 M53 A54 M56 R59 Y61 C62 G63 K64 H66 T68
BS02	ZN	DS	C163 C168 C186	C42 C47 C65

External links

• PDB: RCSB:8cq7, PDBe:8cq7, PDBj:8cq7
• PDBsum: 8cq7
• UniProt: Q5A109|RS31_CANAL Ubiquitin-ribosomal protein eS31 fusion protein (Gene Name=UBI3)