Structure of PDB 4v7l Chain DQ

Receptor sequence

>4v7lDQ (length=139) Species: 300852 (Thermus thermophilus HB8)

MLMPRRMKYRKQQRGRLKGATKGGDYVAFGDYGLVALEPAWITAQQIEAA
RVAMVRHFRRGGKIFIRIFPDKPYTKKPLEVRMGKGKGNVEGYVAVVKPG
RVMFEVAGVTEEQAMEALRIAGHKLPIKTKIVRRDAYDE

3D structure

• PDB: 4v7l The structures of the anti-tuberculosis antibiotics viomycin and capreomycin bound to the 70S ribosome.
• Chain: DQ
• Resolution: 3.0 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	DQ	V52 R56	V52 R56
BS02	rna	DQ	R5 R6 K8 Y9 K11 Q12 Q13 R14 G15 R16 L17 K22 G23 G24 Y26 F29 W41 Q45 Q46 A49 K63 F65 R67 F69 D71 Y74 T75 K76 K77 E80 R82 M83 G84 K85 G86 K87 R119 H123 K124 K128	R5 R6 K8 Y9 K11 Q12 Q13 R14 G15 R16 L17 K22 G23 G24 Y26 F29 W41 Q45 Q46 A49 K63 F65 R67 F69 D71 Y74 T75 K76 K77 E80 R82 M83 G84 K85 G86 K87 R119 H123 K124 K128
BS03	rna	DQ	R16 G19	R16 G19

Gene Ontology

Molecular Function

• GO:0000049 tRNA binding
• GO:0003735 structural constituent of ribosome
• GO:0019843 rRNA binding

Biological Process

• GO:0006412 translation

Cellular Component

• GO:0005840 ribosome
• GO:0022625 cytosolic large ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:4v7l, PDBe:4v7l, PDBj:4v7l
• PDBsum: 4v7l
• PubMed: 20154709
• UniProt: P60489|RL16_THET8 Large ribosomal subunit protein uL16 (Gene Name=rplP)