Structure of PDB 4v7u Chain DO

Receptor sequence

>4v7uDO (length=116) Species: 83333 (Escherichia coli K-12)

DKKSARIRRATRARRKLQELGATRLVVHRTPRHIYAQVIAPNGSEVLVAA
STVEKAIAEQLKYTGNKDAAAAVGKAVAERALEKGIKDVSFDRSGFQYHG
RVQALADAAREAGLQF

3D structure

• PDB: 4v7u Structures of the Escherichia coli ribosome with antibiotics bound near the peptidyl transferase center explain spectra of drug action.
• Chain: DO
• Resolution: 3.1 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	DO	R9 R10 R13 R16 L21 S91 F92 R94 Y99	R8 R9 R12 R15 L20 S90 F91 R93 Y98
BS02	rna	DO	K4 R15 R25 V27 H29 R30 T31 P32 R33 H34 Y36 Q38 I40 N43 G44 S45 V47 V54 Y64 N67 K68 F97 Q98 H100 G101 R102	K3 R14 R24 V26 H28 R29 T30 P31 R32 H33 Y35 Q37 I39 N42 G43 S44 V46 V53 Y63 N66 K67 F96 Q97 H99 G100 R101

Gene Ontology

Molecular Function

• GO:0003735 structural constituent of ribosome
• GO:0008097 5S rRNA binding
• GO:0019843 rRNA binding

Biological Process

• GO:0002181 cytoplasmic translation
• GO:0006412 translation

Cellular Component

• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0005840 ribosome
• GO:0022625 cytosolic large ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:4v7u, PDBe:4v7u, PDBj:4v7u
• PDBsum: 4v7u
• PubMed: 20876128
• UniProt: P0C018|RL18_ECOLI Large ribosomal subunit protein uL18 (Gene Name=rplR)