Structure of PDB 4u26 Chain DJ

Receptor sequence

>4u26DJ (length=142) Species: 83333 (Escherichia coli K-12) [Search protein sequence]

MKTFTAKPETVKRDWYVVDATGKTLGRLATELARRLRGKHKAEYTPHVDT
GDYIIVLNADKVAVTGNKRTDKVYYHHTGHIGGIKQATFEEMIARRPERV
IEIAVKGMLPKGPLGRAMFRKLKVYAGNEHNHAAQQPQVLDI

3D structure

PDB

4u26 Synergy of streptogramin antibiotics occurs independently of their effects on translation.

Chain

Resolution

2.8 Å

3D
structure

Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	DJ	K2 T3 K7 P8 W15 T24 G26 R27 T30 R34 R37 K39 H47 Y53 T65 G66 K68 Y74 Y75 H76 H77 T78 H80 I81 G82 K85 R95 R99 E102 I103 A104 G107 M108 P110 K111 P113 L114 R116 R120 N131 H132 A134 Q135 Q136	K2 T3 K7 P8 W15 T24 G26 R27 T30 R34 R37 K39 H47 Y53 T65 G66 K68 Y74 Y75 H76 H77 T78 H80 I81 G82 K85 R95 R99 E102 I103 A104 G107 M108 P110 K111 P113 L114 R116 R120 N131 H132 A134 Q135 Q136

Gene Ontology

	Molecular Function
GO:0003729	mRNA binding
GO:0003735	structural constituent of ribosome
GO:0008270	zinc ion binding
GO:0048027	mRNA 5'-UTR binding
GO:0070180	large ribosomal subunit rRNA binding

	Biological Process
GO:0002181	cytoplasmic translation
GO:0006412	translation
GO:0017148	negative regulation of translation

	Cellular Component
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005840	ribosome
GO:0022625	cytosolic large ribosomal subunit
GO:1990904	ribonucleoprotein complex

External links

PDB	RCSB:4u26, PDBe:4u26, PDBj:4u26
PDBsum	4u26
PubMed	24957822
UniProt	P0AA10\|RL13_ECOLI Large ribosomal subunit protein uL13 (Gene Name=rplM)