Structure of PDB 5on6 Chain DI

Receptor sequence

>5on6DI (length=112) Species: 559292 (Saccharomyces cerevisiae S288C)

AQRVTFRRRNPYNTRSNKIKVVKTPGGILRAQHVKKLATRPKCGDCGSAL
QGISTLRPRQYATVSKTHKTVSRAYGGSRCANCVKERIIRAFLIEEQKIV
KKVVKEQTEAAK

3D structure

• PDB: 5on6 The Amaryllidaceae Alkaloid Haemanthamine Binds the Eukaryotic Ribosome to Repress Cancer Cell Growth.
• Chain: DI
• Resolution: 3.1 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	DI	A2 R4 V5 T6 F7 R8 R9 R10 N11 P12 Y13 N14 T15 R16 S17 K24 T25 P26 G27 L30 R31 Q33 K36 K37 T40 R41 P42 K43 G45 Q52 G53 I54 S55 T56 R58 P59 R60 T64 S66 K67 T68 K70 T71 S73 R74 A75 Y76 G78 S79 R80 A82 N83 R88 R91 A92 I95 E96 Q98 K102	A1 R3 V4 T5 F6 R7 R8 R9 N10 P11 Y12 N13 T14 R15 S16 K23 T24 P25 G26 L29 R30 Q32 K35 K36 T39 R40 P41 K42 G44 Q51 G52 I53 S54 T55 R57 P58 R59 T63 S65 K66 T67 K69 T70 S72 R73 A74 Y75 G77 S78 R79 A81 N82 R87 R90 A91 I94 E95 Q97 K101
BS02	MG	DI	G53 T71	G52 T70

Gene Ontology

Molecular Function

• GO:0003735 structural constituent of ribosome

Biological Process

• GO:0002181 cytoplasmic translation
• GO:0006412 translation
• GO:0042254 ribosome biogenesis

Cellular Component

• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0005840 ribosome
• GO:0022625 cytosolic large ribosomal subunit
• GO:0030687 preribosome, large subunit precursor
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:5on6, PDBe:5on6, PDBj:5on6
• PDBsum: 5on6
• PubMed: 29429877
• UniProt: P87262|RL34A_YEAST Large ribosomal subunit protein eL34A (Gene Name=RPL34A)