Structure of PDB 4v7s Chain DF

Receptor sequence

>4v7sDF (length=178) Species: 83333 (Escherichia coli K-12) [Search protein sequence]

AKLHDYYKDEVVKKLMTEFNYNSVMQVPRVEKITLNMGVGEAIADKKLLD
NAAADLAAISGQKPLITKARKSVAGFKIRQGYPIGCKVTLRGERMWEFFE
RLITIAVPRIRDFRGLSAKSFDGRGNYSMGVREQIIFPEIDYDKVDRVRG
LDITITTTAKSDEEGRALLAAFDFPFRK

3D structure

PDB

4v7s Structures of the Escherichia coli ribosome with antibiotics bound near the peptidyl transferase center explain spectra of drug action.

Chain

Resolution

3.2547 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	DF	K32 T34 N36 G38 G40 T67 R70 K71 F76 I78 I84 K119 S120 F121 D122 N126 S128 G130 R132 R149 G150 D152 T154 T156	K32 T34 N36 G38 G40 T67 R70 K71 F76 I78 I84 K119 S120 F121 D122 N126 S128 G130 R132 R149 G150 D152 T154 T156
BS02	rna	DF	S23 V24 M25 K63 L65 K68 K87 V88 T89 R91	S23 V24 M25 K63 L65 K68 K87 V88 T89 R91

Gene Ontology

	Molecular Function
GO:0000049	tRNA binding
GO:0003723	RNA binding
GO:0003735	structural constituent of ribosome
GO:0008097	5S rRNA binding
GO:0019843	rRNA binding

	Biological Process
GO:0000027	ribosomal large subunit assembly
GO:0002181	cytoplasmic translation
GO:0006412	translation

	Cellular Component
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005840	ribosome
GO:0022625	cytosolic large ribosomal subunit
GO:1990904	ribonucleoprotein complex

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:4v7s, PDBe:4v7s, PDBj:4v7s
PDBsum	4v7s
PubMed	20876128
UniProt	P62399\|RL5_ECOLI Large ribosomal subunit protein uL5 (Gene Name=rplE)

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