Structure of PDB 4v64 Chain DF

Receptor sequence

>4v64DF (length=178) Species: 562 (Escherichia coli) [Search protein sequence]

AKLHDYYKDEVVKKLMTEFNYNSVMQVPRVEKITLNMGVGEAIADKKLLD
NAAADLAAISGQKPLITKARKSVAGFKIRQGYPIGCKVTLRGERMWEFFE
RLITIAVPRIRDFRGLSAKSFDGRGNYSMGVREQIIFPEIDYDKVDRVRG
LDITITTTAKSDEEGRALLAAFDFPFRK

3D structure

PDB

4v64 Structural basis for hygromycin B inhibition of protein biosynthesis

Chain

Resolution

3.5 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	DF	S23 V24 M25 Q26 K63 L65 V88 T89 R91	S23 V24 M25 Q26 K63 L65 V88 T89 R91
BS02	rna	DF	T34 N36 G38 V39 G40 E41 T67 A69 R70 K71 G75 F76 I84 K87 F121 G130 R132 G150 L151 D152 T154	T34 N36 G38 V39 G40 E41 T67 A69 R70 K71 G75 F76 I84 K87 F121 G130 R132 G150 L151 D152 T154

Gene Ontology

	Molecular Function
GO:0000049	tRNA binding
GO:0003723	RNA binding
GO:0003735	structural constituent of ribosome
GO:0008097	5S rRNA binding
GO:0019843	rRNA binding

	Biological Process
GO:0000027	ribosomal large subunit assembly
GO:0002181	cytoplasmic translation
GO:0006412	translation

	Cellular Component
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005840	ribosome
GO:0022625	cytosolic large ribosomal subunit
GO:1990904	ribonucleoprotein complex

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:4v64, PDBe:4v64, PDBj:4v64
PDBsum	4v64
PubMed	18567815
UniProt	P62399\|RL5_ECOLI Large ribosomal subunit protein uL5 (Gene Name=rplE)

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