Structure of PDB 4u24 Chain DF

Receptor sequence

>4u24DF (length=177) Species: 83333 (Escherichia coli K-12) [Search protein sequence]

AKLHDYYKDEVVKKLMTEFNYNSVMQVPRVEKITLNMGVGEAIADKKLLD
NAAADLAAISGQKPLITKARKSVAGFKIRQGYPIGCKVTLRGERMWEFFE
RLITIAVPRIRDFRGLSAKSFDGRGNYSMGVREQIIFPEIDYDKVDRVRG
LDITITTTAKSDEEGRALLAAFDFPFR

3D structure

PDB

4u24 Synergy of streptogramin antibiotics occurs independently of their effects on translation.

Chain

Resolution

2.9 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	DF	K33 N37 G39 T68 R71 F77 I79 I85 D123 R125 M130 G131 V132 G151 L152 D153 T155	K32 N36 G38 T67 R70 F76 I78 I84 D122 R124 M129 G130 V131 G150 L151 D152 T154
BS02	rna	DF	S24 V25 M26 Q27 Q63 K64 L66 K69 K88 V89 T90 R92 K161	S23 V24 M25 Q26 Q62 K63 L65 K68 K87 V88 T89 R91 K160

Gene Ontology

	Molecular Function
GO:0000049	tRNA binding
GO:0003723	RNA binding
GO:0003735	structural constituent of ribosome
GO:0008097	5S rRNA binding
GO:0019843	rRNA binding

	Biological Process
GO:0000027	ribosomal large subunit assembly
GO:0002181	cytoplasmic translation
GO:0006412	translation

	Cellular Component
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005840	ribosome
GO:0022625	cytosolic large ribosomal subunit
GO:1990904	ribonucleoprotein complex

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:4u24, PDBe:4u24, PDBj:4u24
PDBsum	4u24
PubMed	24957822
UniProt	P62399\|RL5_ECOLI Large ribosomal subunit protein uL5 (Gene Name=rplE)

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